| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Mattia Cassani | 37 | 37 | - | - | 1 | - |
Simon Kjaer | 35 | 35 | - | - | 1 | 2 |
Antonio Nocerino | 35 | 32 | 5 | 3 | 5 | 2 |
Fabrizio Miccoli | 35 | 32 | 3 | 3 | 15 | 19 |
Federico Balzaretti | 34 | 34 | - | - | 2 | 1 |
Edinson Cavani | 34 | 31 | 3 | 3 | 18 | 13 |
Javier Pastore | 34 | 27 | 10 | 7 | 17 | 3 |
Salvatore Sirigu | 32 | 32 | 5 | - | - | - |
Giulio Migliaccio | 30 | 28 | 4 | 2 | 3 | 1 |
Igor Budan | 30 | 5 | 30 | 25 | 5 | 5 |
Cesare Bovo | 29 | 29 | 1 | - | - | 2 |
Fabio Simplicio | 27 | 21 | 7 | 6 | 12 | 3 |
Fabio Liverani | 21 | 20 | 1 | 1 | 4 | - |
Abel Hernandez | 21 | 8 | 18 | 13 | 7 | 7 |
Nicolas Bertolo | 21 | 5 | 32 | 16 | 5 | - |
Marco Bresciano | 18 | 18 | 2 | - | 5 | 1 |
Dorin Goian | 14 | 12 | 24 | 2 | - | - |
Manuele Blasi | 14 | 4 | 24 | 10 | 3 | - |
Rubinho | 6 | 6 | 11 | - | - | - |
Davide Succi | 6 | - | 12 | 6 | - | - |
Giovanni Tedesco | 4 | - | 6 | 4 | - | - |
Cristian Melinte | 2 | 1 | 12 | 1 | 1 | - |
Levan Mchedlidze | 2 | - | 3 | 2 | - | - |
Marco Calderoni | 1 | 1 | 9 | - | 1 | - |
Ondrej Celustka | 1 | - | 10 | 1 | - | - |
Michel Morganella | - | - | 4 | - | - | - |
Giacomo Brichetto | - | - | 5 | - | - | - |
Marco Giovio | - | - | 1 | - | - | - |
Francesco Benussi | - | - | 16 | - | - | - |
Daniele Conti | - | - | 1 | - | - | - |
Daniel Cappelletti | - | - | 1 | - | - | - | 523 | 418 | 260 | 105 | 105 | 59 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .