| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Sergio Aguero | 8 | 6 | 2 | 2 | 4 | 3 |
Raul Garcia | 8 | 6 | 2 | 2 | 4 | 1 |
Maniche | 8 | 4 | 4 | 4 | 1 | 1 |
Diego Forlan | 7 | 5 | 2 | 2 | 2 | 1 |
Florent Sinama-Pongolle | 7 | 4 | 4 | 3 | 3 | - |
Maxi Rodriguez | 6 | 6 | - | - | 4 | 3 |
Luis Perea | 6 | 6 | - | - | - | - |
Antonio Lopez | 6 | 6 | 1 | - | - | - |
Leo Franco | 6 | 6 | 2 | - | - | - |
Simao Sabrosa | 6 | 6 | - | - | 1 | 2 |
Paulo Assuncao | 6 | 5 | 2 | 1 | - | - |
Tomas Ujfalusi | 5 | 5 | 1 | - | - | - |
Luis Garcia | 5 | 3 | 3 | 2 | 1 | - |
Miguel de las Cuevas | 5 | 1 | 6 | 4 | 1 | - |
John Heitinga | 4 | 4 | 3 | - | 1 | - |
Georgios Seitaridis | 4 | 4 | 1 | - | - | - |
Pablo Ibanez | 4 | 3 | 2 | 1 | - | - |
Mariano Pernia | 3 | 3 | 4 | - | - | - |
Ever Banega | 3 | 1 | 4 | 2 | - | - |
Gregory Coupet | 2 | 2 | 5 | - | - | - |
Ignacio Camacho | 1 | 1 | 5 | - | 1 | - |
Alvaro Dominguez | 1 | 1 | - | - | - | - |
Angel Bernabe | - | - | 1 | - | - | - | 111 | 88 | 54 | 23 | 23 | 11 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .