| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Wayne Rooney | 13 | 11 | 2 | 2 | 3 | 4 |
John O'Shea | 12 | 12 | 1 | - | - | 1 |
Cristiano Ronaldo | 12 | 11 | 1 | 1 | 1 | 4 |
Rio Ferdinand | 11 | 11 | - | - | 1 | - |
Patrice Evra | 11 | 10 | 1 | 1 | 1 | - |
Ryan Giggs | 11 | 6 | 7 | 5 | 2 | 1 |
Edwin van der Sar | 10 | 10 | - | - | - | - |
Michael Carrick | 9 | 9 | - | - | 1 | - |
Nemanja Vidic | 9 | 9 | 3 | - | - | 1 |
Anderson | 9 | 7 | 4 | 2 | 4 | - |
Ji Sung Park | 9 | 5 | 7 | 4 | 4 | 1 |
Dimitar Berbatov | 9 | 5 | 4 | 4 | 2 | 4 |
Carlos Tevez | 9 | 4 | 9 | 5 | 3 | 2 |
Darren Fletcher | 8 | 8 | 2 | - | 1 | - |
Jonny Evans | 7 | 6 | 7 | 1 | 1 | - |
Nani | 7 | 6 | 4 | 1 | 2 | - |
Paul Scholes | 6 | 3 | 6 | 3 | 3 | - |
Gary Neville | 4 | 3 | 2 | 1 | 2 | - |
Rafael Da Silva | 4 | 2 | 6 | 2 | 2 | - |
Tomasz Kuszczak | 2 | 2 | 4 | - | - | - |
Darron Gibson | 2 | 1 | 4 | 1 | 1 | - |
Wes Brown | 2 | - | 3 | 2 | - | - |
Ben Foster | 1 | 1 | 8 | - | - | - |
Owen Hargreaves | 1 | 1 | - | - | 1 | - |
Ben Amos | - | - | 1 | - | - | - |
Federico Macheda | - | - | 2 | - | - | - |
Rodrigo Possebon | - | - | 1 | - | - | - |
Fabio Da Silva | - | - | 1 | - | - | - |
Richard Eckersley | - | - | 1 | - | - | - | 178 | 143 | 91 | 35 | 35 | 18 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .