| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Sergio Aguero | 37 | 34 | 4 | 3 | 16 | 18 |
Raul Garcia | 37 | 25 | 13 | 12 | 9 | 3 |
Paulo Assuncao | 33 | 33 | 1 | - | 9 | - |
Tomas Ujfalusi | 33 | 33 | - | - | 2 | - |
Simao Sabrosa | 33 | 32 | 2 | 1 | 10 | 8 |
Diego Forlan | 33 | 32 | 1 | 1 | 9 | 32 |
Maxi Rodriguez | 33 | 29 | 5 | 4 | 16 | 6 |
Leo Franco | 32 | 32 | 3 | - | - | - |
Florent Sinama-Pongolle | 30 | 11 | 23 | 19 | 4 | 4 |
Mariano Pernia | 29 | 24 | 8 | 5 | 3 | - |
John Heitinga | 27 | 26 | 4 | 1 | 4 | 2 |
Luis Perea | 26 | 24 | 4 | 2 | 3 | - |
Ever Banega | 24 | 5 | 22 | 19 | 2 | 1 |
Pablo Ibanez | 21 | 17 | 14 | 4 | 3 | 1 |
Maniche | 21 | 16 | 6 | 5 | 7 | 1 |
Antonio Lopez | 19 | 17 | 7 | 2 | 3 | 2 |
Luis Garcia | 19 | 5 | 21 | 14 | 4 | - |
Georgios Seitaridis | 14 | 10 | 11 | 4 | 3 | - |
Miguel de las Cuevas | 11 | 1 | 21 | 10 | 1 | - |
Ignacio Camacho | 8 | 3 | 14 | 5 | 2 | - |
Gregory Coupet | 6 | 6 | 22 | - | - | - |
Alvaro Dominguez | 2 | 2 | 6 | - | - | - |
Alex Quillo | 1 | 1 | - | - | 1 | - |
Cesar Ortiz | - | - | 1 | - | - | - |
Angel Bernabe | - | - | 1 | - | - | - | 529 | 418 | 214 | 111 | 111 | 78 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .