| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Juan Mata | 36 | 34 | 3 | 2 | 10 | 11 |
Raul Albiol | 34 | 33 | 1 | 1 | 3 | 2 |
David Villa | 33 | 33 | - | - | 5 | 28 |
Joaquin | 31 | 27 | 5 | 4 | 15 | 4 |
David Albelda | 30 | 25 | 7 | 5 | 6 | - |
Miguel | 28 | 27 | 2 | 1 | 2 | - |
Emiliano Moretti | 28 | 25 | 5 | 3 | 5 | - |
Ruben Baraja | 28 | 22 | 8 | 6 | 12 | 3 |
Vicente | 27 | 6 | 23 | 21 | 4 | 6 |
Manuel Fernandes | 26 | 20 | 7 | 6 | 10 | 2 |
Carlos Marchena | 25 | 24 | 2 | 1 | 1 | 1 |
Alexis | 24 | 24 | - | - | 1 | 1 |
Hedwiges Maduro | 22 | 18 | 8 | 4 | 4 | 1 |
Pablo Hernandez | 22 | 12 | 16 | 10 | 6 | 3 |
Edu | 21 | 9 | 18 | 12 | 6 | 1 |
Fernando Morientes | 20 | 7 | 20 | 13 | 4 | 1 |
David Silva | 19 | 17 | 2 | 2 | 6 | 4 |
Cesar Sanchez | 18 | 18 | - | - | - | - |
Renan Brito Soares | 18 | 18 | 6 | - | 1 | - |
Michel | 13 | 4 | 12 | 9 | 3 | - |
Miguel Angel Angulo | 10 | 5 | 14 | 5 | 4 | - |
Asier Del Horno | 9 | 6 | 11 | 3 | 3 | - |
Vicente Guaita | 2 | 1 | 17 | 1 | - | - |
Juan Luis Mora | 1 | 1 | - | - | - | - |
Ivan Helguera | 1 | 1 | 4 | - | - | - |
Hugo Viana | 1 | 1 | 2 | - | - | - |
Thiago Carleto | 1 | - | 5 | 1 | - | - |
Curro Torres | 1 | - | 5 | 1 | - | - |
Nikola Zigic | - | - | 2 | - | - | - | 529 | 418 | 205 | 111 | 111 | 68 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .