| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Gaetano D'Agostino | 36 | 34 | 3 | 2 | 9 | 11 |
Gokhan Inler | 36 | 32 | 5 | 4 | 4 | 1 |
Fabio Quagliarella | 35 | 24 | 12 | 11 | 11 | 13 |
Samir Handanovic | 34 | 34 | - | - | 1 | - |
Simone Pepe | 33 | 29 | 5 | 4 | 15 | 4 |
Antonio Floro Flores | 33 | 22 | 14 | 11 | 12 | 7 |
Mauricio Isla | 32 | 30 | 2 | 2 | 5 | - |
Alexis Sanchez | 31 | 17 | 17 | 14 | 11 | 2 |
Aleksander Lukovic | 27 | 22 | 6 | 5 | 2 | - |
Giovanni Pasquale | 27 | 21 | 14 | 6 | 7 | 3 |
Muarizio Domizzi | 25 | 23 | 7 | 2 | - | 1 |
Andrea Coda | 24 | 24 | 1 | - | - | - |
Antonio Di Natale | 22 | 15 | 7 | 7 | 9 | 12 |
Kwadwo Asamoah | 20 | 19 | 4 | 1 | 4 | 2 |
Cristian Zapata | 18 | 17 | 4 | 1 | - | 1 |
Christian Obodo | 18 | 6 | 20 | 12 | 2 | - |
Felipe | 16 | 16 | 5 | - | - | 2 |
Marco Motta | 14 | 8 | 7 | 6 | 1 | - |
Damiano Ferronetti | 13 | 13 | 3 | - | 4 | - |
Odion Ighalo | 6 | 1 | 9 | 5 | - | 1 |
Fernando Tissone | 5 | 2 | 6 | 3 | 2 | - |
Emanuele Belardi | 4 | 4 | 18 | - | - | - |
Niki Zimling | 4 | 2 | 12 | 2 | 1 | - |
Luigi Sala | 2 | 2 | 15 | - | - | - |
Alain Nef | 2 | - | 5 | 2 | - | - |
Giampiero Pinzi | 1 | 1 | - | - | 1 | 1 |
Jan Koprivec | 1 | - | 7 | 1 | - | - |
Asamoah Gyan | - | - | 1 | - | - | - |
Nikola Vujadinovic | - | - | 1 | - | - | - |
Alessandro Osso | - | - | 1 | - | - | - |
Mahamadou Sissoko | - | - | 1 | - | - | - |
Daniel Bradaschia | - | - | 1 | - | - | - | 519 | 418 | 213 | 101 | 101 | 61 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .