| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Matteo Brighi | 35 | 32 | 5 | 3 | 5 | 3 |
Daniele De Rossi | 33 | 33 | - | - | 1 | 3 |
John Arne Riise | 31 | 30 | 1 | 1 | 1 | 2 |
Rodrigo Taddei | 29 | 24 | 5 | 5 | 14 | 1 |
Jeremy Menez | 29 | 12 | 19 | 17 | 11 | 4 |
Philippe Mexes | 28 | 28 | 1 | - | 2 | 2 |
Doni | 27 | 27 | - | - | 1 | - |
Mirko Vucinic | 27 | 24 | 4 | 3 | 13 | 11 |
Julio Baptista | 27 | 23 | 5 | 4 | 7 | 9 |
Simone Perrotta | 25 | 22 | 3 | 3 | 9 | 5 |
David Pizarro | 24 | 20 | 7 | 4 | 5 | 2 |
Francesco Totti | 23 | 22 | 1 | 1 | 11 | 13 |
Christian Panucci | 22 | 21 | 4 | 1 | 2 | 3 |
Cicinho | 22 | 16 | 9 | 6 | 5 | 1 |
Juan | 21 | 20 | 2 | 1 | 4 | 2 |
Marco Cassetti | 20 | 13 | 9 | 7 | 4 | - |
Alberto Aquilani | 14 | 7 | 8 | 7 | 2 | 2 |
Max Tonetto | 13 | 10 | 10 | 3 | 1 | - |
Marco Motta | 12 | 11 | 2 | 1 | 1 | - |
Vincenzo Montella | 12 | - | 23 | 12 | - | - |
Artur Moraes | 11 | 10 | 19 | 1 | - | - |
Simone Loria | 10 | 6 | 17 | 4 | 2 | 1 |
Stefano Okaka | 9 | 2 | 9 | 7 | 1 | - |
Souleymane Diamoutene | 4 | 2 | 11 | 2 | - | - |
Filipe | 4 | 1 | 10 | 3 | - | - |
Marco D'Alessandro | 3 | - | 4 | 3 | - | - |
Julio Sergio | 1 | 1 | 7 | - | - | - |
Daniele Magliocchetti | 1 | 1 | - | - | - | - |
Valerio Virga | 1 | - | 3 | 1 | - | - |
Alessandro Crescenzi | 1 | - | 2 | 1 | - | - |
Adrian Stoian | 1 | - | 1 | 1 | - | - |
Alessandro Malomo | - | - | 2 | - | - | - |
Riccardo Brosco | - | - | 2 | - | - | - | 520 | 418 | 205 | 102 | 102 | 64 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .