| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Matteo Contini | 34 | 31 | 3 | 3 | - | - |
German Denis | 34 | 22 | 16 | 12 | 11 | 8 |
Marek Hamsik | 32 | 31 | 2 | 1 | 11 | 9 |
Manuele Blasi | 32 | 31 | 3 | 1 | 8 | - |
Paolo Cannavaro | 30 | 30 | 1 | - | 4 | - |
Ezequiel Ivan Lavezzi | 30 | 29 | 1 | 1 | 4 | 7 |
Michele Pazienza | 29 | 18 | 14 | 11 | 9 | 1 |
Fabiano Santacroce | 27 | 27 | 4 | - | 7 | - |
Marcelo Zalayeta | 27 | 17 | 11 | 10 | 8 | 4 |
Walter Gargano | 26 | 23 | 3 | 3 | 1 | - |
Daniele Mannini | 24 | 21 | 4 | 3 | 7 | 1 |
Christian Maggio | 23 | 22 | 2 | 1 | 5 | 4 |
Salvatore Aronica | 23 | 15 | 10 | 8 | 1 | - |
Nicolas Navarro | 19 | 18 | 6 | 1 | 1 | - |
Luigi Vitale | 18 | 17 | 5 | 1 | 9 | 1 |
Leandro Rinaudo | 17 | 13 | 14 | 4 | 1 | - |
Joao Batista Pia | 15 | 8 | 12 | 7 | 6 | 4 |
Mariano Bogliacino | 15 | 8 | 12 | 7 | 3 | 2 |
Andrea Russotto | 15 | - | 21 | 15 | - | - |
Gennaro Iezzo | 14 | 14 | - | - | 1 | - |
Francesco Montervino | 12 | 6 | 18 | 6 | 2 | 1 |
Jesus Datolo | 9 | 3 | 8 | 6 | 1 | - |
Matteo Gianello | 6 | 5 | 8 | 1 | 1 | - |
Gianluca Grava | 6 | 5 | 9 | 1 | 1 | - |
Nicolas Amodio | 3 | 3 | 2 | - | 2 | - |
Luca Bucci | 1 | 1 | 9 | - | - | - |
Luigi Sepe | 1 | - | 1 | 1 | - | - |
Samuele Dalla Bona | - | - | 1 | - | - | - | 522 | 418 | 200 | 104 | 104 | 42 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .