| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Sebastian Frey | 37 | 37 | - | - | - | - |
Alessandro Gamberini | 35 | 34 | 2 | 1 | - | - |
Alberto Gilardino | 35 | 34 | 1 | 1 | 8 | 19 |
Riccardo Montolivo | 34 | 32 | 2 | 2 | 5 | 4 |
Zdravko Kuzmanovic | 31 | 25 | 8 | 6 | 18 | 2 |
Felipo Melo | 29 | 29 | - | - | 2 | 2 |
Marco Donadel | 29 | 19 | 14 | 10 | 5 | - |
Stevan Jovetic | 29 | 19 | 13 | 10 | 12 | 2 |
Gianluca Comotto | 28 | 25 | 5 | 3 | 3 | - |
Juan Manuel Vargas | 27 | 24 | 4 | 3 | 9 | 3 |
Dario Dainelli | 21 | 20 | 5 | 1 | 3 | 1 |
Franco Semioli | 21 | 13 | 13 | 8 | 5 | - |
Per Kroldrup | 20 | 18 | 9 | 2 | 1 | - |
Mario Santana | 20 | 17 | 3 | 3 | 7 | 1 |
Adrian Mutu | 19 | 19 | - | - | 9 | 13 |
Manuel Pasqual | 19 | 15 | 8 | 4 | 2 | 1 |
Luciano Zauri | 18 | 13 | 16 | 5 | 2 | 1 |
Massimo Gobbi | 16 | 6 | 14 | 10 | 2 | 1 |
Giampaolo Pazzini | 12 | 3 | 10 | 9 | 1 | 1 |
Emiliano Bonazzoli | 12 | 1 | 14 | 11 | - | 1 |
Sergio Almiron | 11 | 6 | 11 | 5 | 4 | - |
Martin Jorgensen | 10 | 5 | 7 | 5 | 4 | 1 |
Dani Osvaldo | 7 | 2 | 8 | 5 | 2 | - |
Marco Storari | 1 | 1 | 23 | - | - | - |
Manuel Da Costa | 1 | 1 | 4 | - | - | - |
Nikola Gulan | - | - | 1 | - | - | - |
Vlada Avramov | - | - | 2 | - | - | - |
Pape Moussa Diakhate | - | - | 1 | - | - | - |
Massimiliano Tagliani | - | - | 4 | - | - | - |
Maritato Piergiuseppe | - | - | 2 | - | - | - |
Piergiuseppe Maritato | - | - | 1 | - | - | - |
Ondrej Mazuch | - | - | 3 | - | - | - | 522 | 418 | 208 | 104 | 104 | 53 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .