| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Javier Zanetti | 38 | 37 | 1 | 1 | - | - |
Zlatan Ibrahimovic | 35 | 35 | 1 | - | 3 | 25 |
Julio Cesar | 35 | 35 | - | - | 2 | - |
Esteban Cambiasso | 34 | 33 | 2 | 1 | 1 | 4 |
Dejan Stankovic | 31 | 26 | 6 | 5 | 15 | 5 |
Maicon | 28 | 27 | 1 | 1 | - | 4 |
Ivan Cordoba | 28 | 26 | 9 | 2 | 1 | 2 |
Sulley Muntari | 27 | 26 | 1 | 1 | 15 | 4 |
Maxwell | 25 | 19 | 8 | 6 | 5 | 1 |
Mario Balotelli | 22 | 15 | 10 | 7 | 8 | 8 |
Cristian Chivu | 21 | 20 | 2 | 1 | 8 | - |
Nicolas Burdisso | 21 | 13 | 13 | 8 | 2 | 1 |
Luis Figo | 21 | 11 | 12 | 10 | 9 | 1 |
Mancini | 21 | 10 | 15 | 11 | 8 | - |
Patrick Vieira | 19 | 10 | 13 | 9 | 5 | 1 |
Walter Samuel | 17 | 17 | 4 | - | 2 | 1 |
Julio Cruz | 17 | 7 | 19 | 10 | 6 | 2 |
Davide Santon | 16 | 14 | 5 | 2 | 3 | - |
Hernan Crespo | 14 | 2 | 22 | 12 | 2 | 2 |
Adriano | 12 | 9 | 7 | 3 | 5 | 3 |
Ricardo Quaresma | 12 | 7 | 9 | 5 | 5 | 1 |
Marco Materazzi | 8 | 8 | 12 | - | 2 | - |
Victor Obinna | 8 | 3 | 8 | 5 | 2 | 1 |
Nelson Rivas | 6 | 3 | 4 | 3 | - | - |
Luis Jimenez | 6 | 2 | 8 | 4 | 3 | - |
Francesco Toldo | 3 | 2 | 23 | 1 | - | - |
Cesar Aparecido | 1 | 1 | - | - | - | - |
Olivier Dacourt | 1 | - | 3 | 1 | - | - |
Hugo Gomes Pele | 1 | - | 1 | 1 | - | - |
Paulo Orlandoni | 1 | - | 5 | 1 | - | - |
Francesco Bolzoni | 1 | - | 1 | 1 | - | - | 530 | 418 | 225 | 112 | 112 | 66 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .