| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Alexandre Pato | 36 | 27 | 9 | 9 | 15 | 15 |
Gianluca Zambrotta | 34 | 33 | 1 | 1 | 2 | 1 |
Marek Jankulovski | 31 | 31 | 3 | - | 3 | - |
Kaka | 31 | 28 | 3 | 3 | 6 | 16 |
Paolo Maldini | 30 | 30 | 1 | - | 2 | - |
Mathieu Flamini | 29 | 22 | 9 | 7 | 6 | - |
Christian Abbiati | 28 | 28 | - | - | 1 | - |
Massimo Ambrosini | 28 | 24 | 6 | 4 | 6 | 7 |
Ronaldinho Gaucho | 28 | 16 | 16 | 12 | 7 | 7 |
Filippo Inzaghi | 26 | 15 | 17 | 11 | 12 | 13 |
Andrea Pirlo | 25 | 25 | - | - | 1 | 1 |
Chedric Seedorf | 25 | 21 | 4 | 4 | 6 | - |
Giuseppe Favalli | 23 | 21 | 8 | 2 | 3 | - |
David Beckham | 18 | 18 | 2 | - | 12 | 2 |
Daniele Bonera | 18 | 16 | 3 | 2 | 2 | - |
Andriy Shevchenko | 18 | 2 | 27 | 16 | 2 | - |
Philippe Senderos | 13 | 7 | 14 | 6 | - | - |
Gennaro Gattuso | 12 | 11 | 4 | 1 | 5 | - |
Emerson | 12 | 3 | 16 | 9 | 3 | - |
Kakha Kaladze | 11 | 10 | 5 | 1 | 2 | - |
Dida | 10 | 9 | 21 | 1 | - | - |
Clarence Seedorf | 9 | 9 | 4 | - | 3 | 6 |
Luca Antonelli | 9 | 4 | 15 | 5 | 2 | - |
Marco Borriello | 7 | 6 | 2 | 1 | 4 | 1 |
Matteo Darmian | 3 | - | 7 | 3 | - | - |
Luca Antonini | 2 | - | 6 | 2 | - | - |
Marcus Diniz | 1 | 1 | - | - | - | - |
Zeljko Kalac | 1 | 1 | 9 | - | - | - |
Alessandro Nesta | 1 | - | 2 | 1 | - | - |
Mathias Cardaccio | 1 | - | 10 | 1 | - | - |
Tabare Viudez | 1 | - | 1 | 1 | - | - |
Rodney Strasser | 1 | - | 1 | 1 | - | - |
Felipe Mattioni | 1 | - | 4 | 1 | - | - |
Nicola Pasini | - | - | 1 | - | - | - |
Wilfred Osuji | - | - | 1 | - | - | - | 523 | 418 | 232 | 105 | 105 | 69 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .