| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Pavel Nedved | 32 | 28 | 5 | 4 | 3 | 7 |
Amauri | 32 | 27 | 6 | 5 | 11 | 12 |
Zdenek Grygera | 31 | 28 | 3 | 3 | 4 | 2 |
Alessandro Del Piero | 31 | 28 | 5 | 3 | 12 | 13 |
Cristian Molinaro | 29 | 29 | - | - | 3 | - |
Marco Marchionni | 29 | 21 | 13 | 8 | 9 | 1 |
Vincenzo Iaquinta | 28 | 18 | 12 | 10 | 4 | 11 |
Giorgio Chiellini | 27 | 27 | 1 | - | 1 | 4 |
Olaf Mellberg | 27 | 23 | 8 | 4 | 2 | 2 |
Nicola Legrottaglie | 26 | 26 | 1 | - | 2 | 1 |
Gianluigi Buffon | 23 | 23 | - | - | 1 | - |
Christian Poulsen | 23 | 14 | 11 | 9 | 4 | 1 |
Claudio Marchisio | 22 | 18 | 6 | 4 | 5 | 3 |
Mohamed Sissoko | 21 | 20 | 2 | 1 | 7 | 2 |
Paolo De Ceglie | 19 | 11 | 13 | 8 | 5 | - |
Sebastian Giovinco | 19 | 9 | 21 | 10 | 6 | 2 |
Mauro Camoranesi | 18 | 13 | 7 | 5 | 7 | 1 |
Alex Manninger | 16 | 15 | 12 | 1 | - | - |
Tiago | 15 | 12 | 11 | 3 | 6 | - |
Cristiano Zanetti | 12 | 9 | 3 | 3 | 6 | 2 |
Hasan Salihamidzic | 11 | 7 | 8 | 4 | 1 | 1 |
Jonathan Zebina | 8 | 4 | 7 | 4 | 2 | - |
David Trezeguet | 8 | 2 | 14 | 6 | - | 1 |
Dario Knezevic | 4 | 4 | 5 | - | - | - |
Lorenzo Ariaudo | 3 | 2 | 9 | 1 | - | - |
Albin Ekdal | 3 | - | 7 | 3 | - | - |
Ciro Immobile | 1 | - | 1 | 1 | - | - |
Ayub Daud | 1 | - | 1 | 1 | - | - |
Simone Esposito | - | - | 1 | - | - | - |
Iago Falque | - | - | 2 | - | - | 1 |
Antonio Chimenti | - | - | 13 | - | - | - |
Luca Castiglia | - | - | 2 | - | - | - |
Fausto Rossi | - | - | 1 | - | - | - | 519 | 418 | 211 | 101 | 101 | 67 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .