| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Mauro Zarate | 35 | 32 | 3 | 3 | 11 | 13 |
Cristian Ledesma | 34 | 34 | - | - | 1 | 2 |
Stephen Lichtsteiner | 33 | 31 | 3 | 2 | 5 | 1 |
Pasquale Foggia | 32 | 19 | 14 | 13 | 7 | 3 |
Christian Brocchi | 31 | 25 | 7 | 6 | 13 | - |
Goran Pandev | 30 | 28 | 3 | 2 | 11 | 9 |
David Rozehnal | 28 | 25 | 8 | 3 | - | - |
Sebastiano Siviglia | 27 | 26 | 1 | 1 | 1 | 2 |
Tommaso Rocchi | 27 | 15 | 12 | 12 | 4 | 9 |
Stefano Mauri | 26 | 17 | 12 | 9 | 8 | 1 |
Aleksandar Kolarov | 25 | 22 | 9 | 3 | 2 | 2 |
Juan Carrizo | 23 | 23 | 13 | - | - | - |
Mourad Meghni | 22 | 10 | 15 | 12 | 9 | - |
Ousmane Dabo | 21 | 15 | 10 | 6 | 13 | 1 |
Lorenzo De Silvestri | 21 | 12 | 16 | 9 | 2 | - |
Stefan Radu | 19 | 18 | 9 | 1 | 3 | - |
Emilson Cribari | 17 | 16 | 10 | 1 | 3 | - |
Fernando Muslera | 15 | 15 | 15 | - | - | - |
Matuzalem | 14 | 13 | 2 | 1 | 4 | - |
Modibo Diakite | 9 | 9 | 8 | - | 2 | 1 |
Simone Inzaghi | 9 | - | 11 | 9 | - | 1 |
Christian Manfredini | 7 | 3 | 14 | 4 | 3 | - |
Simone Del Nero | 6 | 5 | 2 | 1 | 5 | - |
Ettore Mendicino | 4 | 1 | 5 | 3 | 1 | - |
Ayodele Stephen Makinwa | 4 | - | 8 | 4 | - | - |
Libor Kozak | 3 | 1 | 3 | 2 | - | - |
Manuel Belleri | 1 | 1 | 1 | - | 1 | - |
Roberto Baronio | 1 | 1 | - | - | - | - |
Massimo Mutarelli | 1 | 1 | - | - | - | - |
Alessandro Tuia | 1 | - | 4 | 1 | - | - |
Riccardo Perpetuini | 1 | - | 4 | 1 | - | - |
Fabio Firmani | - | - | 1 | - | - | - |
Marco Davide Faraoni | - | - | 1 | - | - | - | 527 | 418 | 224 | 109 | 109 | 45 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .