| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Fabio Simplicio | 37 | 36 | 1 | 1 | 9 | 8 |
Mattia Cassani | 36 | 36 | - | - | 3 | 1 |
Edinson Cavani | 35 | 34 | 1 | 1 | 10 | 14 |
Marco Amelia | 34 | 34 | - | - | 2 | - |
Federico Balzaretti | 33 | 33 | - | - | 1 | - |
Fabio Liverani | 33 | 32 | 2 | 1 | 9 | - |
Antonio Nocerino | 33 | 29 | 5 | 4 | 11 | - |
Fabrizio Miccoli | 30 | 30 | 1 | - | 15 | 14 |
Giulio Migliaccio | 30 | 24 | 9 | 6 | 8 | 3 |
Cesare Bovo | 28 | 27 | 1 | 1 | 2 | 2 |
Simon Kjaer | 27 | 22 | 7 | 5 | 2 | 3 |
Marco Bresciano | 26 | 23 | 3 | 3 | 8 | 4 |
Davide Succi | 24 | 8 | 21 | 16 | 5 | 5 |
Moris Carrozzieri | 23 | 22 | 1 | 1 | 3 | - |
Giovanni Tedesco | 17 | 5 | 18 | 12 | 5 | 1 |
Roberto Guana | 16 | 7 | 15 | 9 | 5 | - |
Mirko Savini | 11 | 2 | 16 | 9 | 1 | - |
Levan Mchedlidze | 9 | 1 | 15 | 8 | 1 | 1 |
David Lanzafame | 9 | - | 10 | 9 | - | - |
Abel Hernandez | 6 | - | 11 | 6 | - | - |
Alberto Fontana | 5 | 4 | 3 | 1 | - | - |
Igor Budan | 5 | 1 | 6 | 4 | 1 | - |
Paolo Hernan Dellafiore | 4 | 3 | 5 | 1 | 1 | - |
Maurizio Ciaramitaro | 3 | - | 5 | 3 | - | - |
Andrea Raggi | 2 | 2 | 3 | - | - | - |
Ciro Capuano | 2 | 2 | 3 | - | 1 | - |
Michel Morganella | 2 | - | 8 | 2 | - | - |
Bosko Jankovic | 1 | 1 | - | - | 1 | - |
Samir Ujkani | 1 | - | 20 | 1 | - | - |
Alberto Cossentino | - | - | 4 | - | - | - |
Luca Di Matteo | - | - | 1 | - | - | - |
Gianvito Misuraca | - | - | 1 | - | - | - | 522 | 418 | 196 | 104 | 104 | 56 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .