| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Nemanja Vidic | 34 | 33 | 1 | 1 | - | 4 |
Edwin van der Sar | 33 | 33 | - | - | 1 | - |
Cristiano Ronaldo | 33 | 31 | 3 | 2 | 5 | 18 |
Dimitar Berbatov | 31 | 29 | 4 | 2 | 7 | 9 |
Wayne Rooney | 30 | 25 | 5 | 5 | 5 | 12 |
John O'Shea | 30 | 20 | 15 | 10 | 4 | - |
Carlos Tevez | 29 | 18 | 16 | 11 | 8 | 5 |
Patrice Evra | 28 | 28 | 1 | - | 4 | - |
Michael Carrick | 28 | 24 | 6 | 4 | 5 | 4 |
Ryan Giggs | 28 | 15 | 17 | 13 | 3 | 2 |
Darren Fletcher | 26 | 25 | 8 | 1 | 9 | 3 |
Ji Sung Park | 25 | 21 | 10 | 4 | 10 | 2 |
Rio Ferdinand | 24 | 24 | - | - | 1 | - |
Paul Scholes | 21 | 14 | 11 | 7 | 6 | 2 |
Jonny Evans | 17 | 16 | 15 | 1 | 2 | - |
Anderson | 17 | 11 | 14 | 6 | 9 | - |
Gary Neville | 16 | 13 | 13 | 3 | 4 | - |
Rafael Da Silva | 16 | 12 | 13 | 4 | 5 | 1 |
Nani | 13 | 7 | 21 | 6 | 6 | 1 |
Wes Brown | 8 | 6 | 4 | 2 | - | 1 |
Tomasz Kuszczak | 4 | 3 | 24 | 1 | - | - |
Federico Macheda | 4 | 2 | 3 | 2 | 1 | 2 |
Danny Welbeck | 3 | 1 | 11 | 2 | 1 | 1 |
Darron Gibson | 3 | 1 | 12 | 2 | - | 1 |
Rodrigo Possebon | 3 | - | 4 | 3 | - | - |
Ben Foster | 2 | 2 | 11 | - | - | - |
Owen Hargreaves | 2 | 1 | 1 | 1 | - | - |
Zoran Tosic | 2 | - | 2 | 2 | - | - |
Richard Eckersley | 2 | - | 6 | 2 | - | - |
Lee Martin | 1 | 1 | 1 | - | - | - |
Ritchie de Laet | 1 | 1 | - | - | 1 | - |
Fraizer Campbell | 1 | 1 | 1 | - | 1 | - |
Manucho Goncalves | 1 | - | 1 | 1 | - | - |
Ben Amos | - | - | 3 | - | - | - |
Matty James | - | - | 1 | - | - | - |
Fabio Da Silva | - | - | 5 | - | - | - |
Corry Evans | - | - | 1 | - | - | - |
James Chester | - | - | 1 | - | - | - |
Daniel Drinkwater | - | - | 1 | - | - | - | 516 | 418 | 266 | 98 | 98 | 68 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .