| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Aaron Lennon | 35 | 26 | 9 | 9 | 8 | 5 |
Heurelho Gomes | 34 | 34 | 2 | - | - | - |
Jonathan Woodgate | 34 | 34 | 1 | - | 3 | 1 |
Luka Modric | 34 | 34 | 1 | - | 12 | 3 |
Vedran Corluka | 34 | 33 | 2 | 1 | 4 | - |
Darren Bent | 33 | 21 | 12 | 12 | 6 | 12 |
Jermaine Jenas | 32 | 28 | 4 | 4 | 6 | 4 |
Benoit Assou-Ekotto | 29 | 29 | 4 | - | 4 | - |
Didier Zokora | 29 | 24 | 13 | 5 | 5 | - |
Roman Pavlyuchenko | 28 | 19 | 13 | 9 | 16 | 5 |
David Bentley | 25 | 20 | 17 | 5 | 7 | 1 |
Ledley King | 24 | 24 | 1 | - | 1 | 1 |
Tom Huddlestone | 22 | 14 | 21 | 8 | 3 | - |
Michael Dawson | 16 | 13 | 16 | 3 | 3 | 1 |
Gareth Bale | 16 | 12 | 17 | 4 | 4 | - |
Jamie O'Hara | 15 | 6 | 19 | 9 | 2 | 1 |
Robbie Keane | 14 | 14 | - | - | 1 | 5 |
Wilson Palacios | 11 | 11 | - | - | 1 | - |
Fraizer Campbell | 10 | 1 | 21 | 9 | - | 1 |
Jermain Defoe | 8 | 6 | 2 | 2 | 1 | 3 |
Alan Hutton | 8 | 5 | 7 | 3 | 1 | - |
Giovani Dos Santos | 6 | 2 | 7 | 4 | 2 | - |
Carlo Cudicini | 4 | 4 | 12 | - | - | - |
Chris Gunter | 3 | 2 | 14 | 1 | 2 | - |
Pascal Chimbonda | 3 | 1 | 10 | 2 | - | - |
Gilberto | 1 | 1 | 4 | - | 1 | - |
Adel Taarabt | 1 | - | 5 | 1 | - | - |
Kevin-Prince Boateng | 1 | - | 4 | 1 | - | - |
Dimitar Berbatov | 1 | - | 1 | 1 | - | - |
Jonathan Obika | - | - | 1 | - | - | - |
Ben Alnwick | - | - | 3 | - | - | - |
Cesar Sanchez | - | - | 21 | - | - | - |
Ricardo Rocha | - | - | 1 | - | - | - |
Danny Rose | - | - | 1 | - | - | - | 511 | 418 | 266 | 93 | 93 | 43 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .