| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Rio Ferdinand | 4 | 4 | - | - | - | - |
Patrice Evra | 4 | 4 | - | - | 1 | - |
Wes Brown | 4 | 4 | - | - | - | - |
Edwin van der Sar | 4 | 4 | - | - | 1 | - |
Michael Carrick | 4 | 3 | 1 | 1 | 1 | - |
Wayne Rooney | 4 | 3 | 1 | 1 | 1 | 2 |
Anderson | 4 | 2 | 2 | 2 | 1 | - |
Nemanja Vidic | 3 | 3 | - | - | - | - |
Cristiano Ronaldo | 3 | 3 | - | - | - | 3 |
Owen Hargreaves | 3 | 2 | 1 | 1 | 1 | - |
Paul Scholes | 3 | 1 | 2 | 2 | - | - |
Nani | 2 | 2 | 2 | - | - | 1 |
Ji Sung Park | 2 | 2 | - | - | 1 | - |
Ryan Giggs | 2 | 2 | - | - | 1 | - |
Carlos Tevez | 2 | 2 | 1 | - | 2 | 1 |
John O'Shea | 2 | 1 | 3 | 1 | - | - |
Louis Saha | 2 | 1 | 2 | 1 | 1 | - |
Darren Fletcher | 1 | 1 | - | - | - | 2 |
Tomasz Kuszczak | 1 | - | 3 | 1 | - | - |
Danny Simpson | 1 | - | 1 | 1 | - | - |
Tom Heaton | - | - | 1 | - | - | - | 55 | 44 | 20 | 11 | 11 | 9 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .