| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Fabio Quagliarella | 38 | 35 | 2 | 3 | 8 | 12 |
Gokhan Inler | 37 | 37 | - | - | 2 | 2 |
Antonio Floro Flores | 37 | 12 | 25 | 25 | 9 | 3 |
Antonio Di Natale | 36 | 35 | 1 | 1 | 13 | 17 |
Samir Handanovic | 35 | 35 | 1 | - | - | - |
Andrea Dossena | 35 | 35 | - | - | 6 | 2 |
Gaetano D'Agostino | 35 | 34 | 1 | 1 | 13 | - |
Simone Pepe | 33 | 23 | 11 | 10 | 8 | 3 |
Aleksander Lukovic | 32 | 29 | 6 | 3 | 1 | - |
Cristian Zapata | 28 | 27 | 1 | 1 | 1 | 1 |
Giandomencio Mesto | 28 | 26 | 3 | 2 | 3 | 2 |
Felipe | 22 | 22 | 1 | - | 3 | 1 |
Tomas Zapotocny | 20 | 19 | 6 | 1 | 9 | - |
Andrea Coda | 20 | 16 | 9 | 4 | - | - |
Damiano Ferronetti | 16 | 11 | 6 | 5 | 8 | 1 |
Asamoah Gyan | 13 | 9 | 4 | 4 | 7 | 3 |
Giampiero Pinzi | 13 | 1 | 14 | 12 | 1 | - |
Mauricio Isla | 10 | 2 | 10 | 8 | - | - |
Roman Eremenko | 7 | 3 | 15 | 4 | 1 | - |
Roberto Colombo | 4 | - | 10 | 4 | - | - |
Antonio Chimenti | 3 | 3 | 10 | - | - | - |
Guilherme Siqueira | 3 | 2 | 4 | 1 | 1 | - |
Tomos Sivok | 2 | 1 | 2 | 1 | 1 | - |
Michele Paolucci | 2 | - | 5 | 2 | - | - |
Antonio Candreva | 2 | - | 4 | 2 | - | - |
Viktor Budyanskiy | 1 | 1 | 2 | - | 1 | - |
Vincent Candela | 1 | - | 2 | 1 | - | - |
Christian Obodo | 1 | - | 1 | 1 | - | - |
Saulo Squarsone | - | - | 4 | - | - | - |
Aoas Vidal Moreno | - | - | 5 | - | - | - |
Raffaele De Martino | - | - | 1 | - | - | - | 514 | 418 | 166 | 96 | 96 | 47 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .