| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Doni | 37 | 37 | - | - | 1 | - |
Max Tonetto | 35 | 33 | 2 | 2 | 5 | 1 |
Daniele De Rossi | 34 | 34 | - | - | 2 | 5 |
Mirko Vucinic | 33 | 23 | 10 | 10 | 10 | 9 |
Ludovic Giuly | 32 | 17 | 16 | 15 | 10 | 6 |
Philippe Mexes | 31 | 30 | 1 | 1 | 2 | 1 |
Mancini | 31 | 28 | 5 | 3 | 20 | 8 |
David Pizarro | 31 | 28 | 3 | 3 | 8 | 3 |
Cicinho | 30 | 18 | 16 | 12 | 3 | 2 |
Simone Perrotta | 29 | 25 | 4 | 4 | 10 | 5 |
Marco Cassetti | 27 | 21 | 6 | 6 | 4 | - |
Rodrigo Taddei | 26 | 25 | 1 | 1 | 18 | 6 |
Christian Panucci | 26 | 20 | 8 | 6 | 2 | 5 |
Francesco Totti | 25 | 25 | 1 | - | 9 | 14 |
Matteo Brighi | 24 | 6 | 20 | 18 | 3 | 1 |
Juan | 23 | 20 | 4 | 3 | 1 | 2 |
Alberto Aquilani | 21 | 11 | 11 | 10 | 3 | 3 |
Matteo Ferrari | 16 | 16 | - | - | 1 | - |
Mauro Esposito | 8 | - | 16 | 8 | - | - |
Vitorino Antunes | 5 | - | 11 | 5 | - | - |
Ahmed Barusso | 3 | - | 5 | 3 | - | - |
Gianluca Curci | 2 | 1 | 10 | 1 | - | - |
Edgar Alvarez Reyes | 1 | - | 1 | 1 | - | - |
Julio Sergio | - | - | 1 | - | - | - |
Daniel Unal | - | - | 2 | - | - | - |
Adrian Pit | - | - | 2 | - | - | - |
Carlo Zotti | - | - | 1 | - | - | - | 530 | 418 | 157 | 112 | 112 | 71 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .