| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Marek Hamsik | 37 | 34 | 3 | 3 | 18 | 9 |
Ezequiel Ivan Lavezzi | 35 | 34 | 1 | 1 | 12 | 7 |
Walter Gargano | 35 | 34 | 1 | 1 | 5 | 2 |
Mariano Bogliacino | 35 | 16 | 22 | 19 | 7 | 3 |
Paolo Cannavaro | 33 | 33 | - | - | - | - |
Roberto Sosa | 30 | 8 | 22 | 22 | 1 | 7 |
Mirko Savini | 29 | 29 | - | - | 10 | - |
Matteo Contini | 29 | 23 | 10 | 6 | 3 | 1 |
Muarizio Domizzi | 28 | 28 | - | - | 2 | 8 |
Manuele Blasi | 27 | 27 | - | - | 5 | - |
Emanuele Calaio | 26 | 7 | 22 | 19 | 5 | 2 |
Gyorgy Garics | 25 | 17 | 10 | 8 | 4 | 1 |
Marcelo Zalayeta | 22 | 21 | 1 | 1 | 11 | 7 |
Gennaro Iezzo | 19 | 19 | 3 | - | - | - |
Gianluca Grava | 19 | 13 | 13 | 6 | 4 | - |
Andrea Cupi | 16 | 16 | 3 | - | 7 | - |
Matteo Gianello | 16 | 16 | 6 | - | - | - |
Daniele Mannini | 15 | 15 | - | - | 7 | 1 |
Fabiano Santacroce | 13 | 11 | 2 | 2 | 2 | - |
Michele Pazienza | 13 | 8 | 6 | 5 | 1 | - |
Francesco Montervino | 9 | 2 | 16 | 7 | 1 | - |
Erminio Rullo | 4 | 2 | 3 | 2 | 2 | - |
Nicolas Navarro | 3 | 3 | 3 | - | - | - |
Roberto De Zerbi | 3 | 1 | 5 | 2 | 1 | - |
Ruben Maldonado | 2 | 1 | 1 | 1 | 1 | - |
Marco Capparella | 2 | - | 5 | 2 | - | - |
Samuele Dalla Bona | 2 | - | 6 | 2 | - | - | 527 | 418 | 164 | 109 | 109 | 48 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .