| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Javier Zanetti | 37 | 35 | 3 | 2 | - | 1 |
Julio Cesar | 35 | 35 | - | - | 2 | - |
Esteban Cambiasso | 33 | 33 | - | - | 4 | 6 |
Maxwell | 32 | 27 | 6 | 5 | 6 | - |
Maicon | 31 | 31 | - | - | 3 | 1 |
Julio Cruz | 28 | 22 | 9 | 6 | 10 | 13 |
David Suazo | 27 | 9 | 19 | 18 | 6 | 8 |
Cristian Chivu | 26 | 23 | 3 | 3 | 5 | - |
Zlatan Ibrahimovic | 25 | 22 | 5 | 3 | 5 | 17 |
Nicolas Burdisso | 24 | 20 | 10 | 4 | - | 1 |
Marco Materazzi | 22 | 16 | 8 | 6 | 4 | 1 |
Ivan Cordoba | 20 | 20 | - | - | - | 3 |
Dejan Stankovic | 20 | 19 | 2 | 1 | 8 | 1 |
Hernan Crespo | 19 | 12 | 12 | 7 | 8 | 4 |
Cesar Aparecido | 17 | 13 | 6 | 4 | 4 | 1 |
Luis Figo | 17 | 10 | 8 | 7 | 7 | 1 |
Patrick Vieira | 16 | 13 | 3 | 3 | 4 | 3 |
Luis Jimenez | 15 | 11 | 8 | 4 | 10 | 3 |
Hugo Gomes Pele | 15 | 4 | 15 | 11 | 1 | - |
Walter Samuel | 12 | 12 | - | - | 1 | - |
Mario Balotelli | 11 | 7 | 4 | 4 | 6 | 3 |
Olivier Dacourt | 10 | 6 | 3 | 4 | 3 | - |
Nelson Rivas | 10 | 6 | 10 | 4 | 2 | - |
Maniche | 8 | 4 | 7 | 4 | 4 | 1 |
Santiago Solari | 5 | 2 | 4 | 3 | 2 | - |
Adriano | 4 | 3 | 1 | 1 | 2 | 1 |
Francesco Toldo | 3 | 2 | 8 | 1 | - | - |
Paulo Orlandoni | 2 | 1 | 5 | 1 | - | - |
Julio Cruz | 1 | - | - | 1 | - | - | 525 | 418 | 159 | 107 | 107 | 69 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .