| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Andrea Pirlo | 33 | 32 | 1 | 1 | 5 | 3 |
Massimo Ambrosini | 33 | 31 | 3 | 2 | 6 | 4 |
Clarence Seedorf | 32 | 31 | 1 | 1 | 8 | 7 |
Kakha Kaladze | 32 | 30 | 2 | 2 | 1 | - |
Gennaro Gattuso | 31 | 30 | 2 | 1 | 18 | 1 |
Kaka | 30 | 30 | - | - | 5 | 15 |
Alberto Gilardino | 30 | 20 | 14 | 10 | 7 | 7 |
Alessandro Nesta | 29 | 28 | 1 | 1 | 2 | 1 |
Giuseppe Favalli | 27 | 19 | 10 | 8 | 7 | - |
Zeljko Kalac | 25 | 25 | 4 | - | - | - |
Massimo Oddo | 25 | 21 | 7 | 4 | 8 | 1 |
Christian Brocchi | 23 | 10 | 17 | 13 | 6 | - |
Daniele Bonera | 21 | 17 | 7 | 4 | 1 | - |
Filippo Inzaghi | 21 | 14 | 8 | 7 | 6 | 11 |
Alexandre Pato | 18 | 13 | 6 | 5 | 5 | 9 |
Paolo Maldini | 17 | 15 | 3 | 2 | 4 | 1 |
Cafu | 15 | 8 | 12 | 7 | 3 | 1 |
Emerson | 15 | 6 | 11 | 9 | 3 | - |
Yoann Gourcuff | 15 | 4 | 17 | 11 | 1 | 1 |
Marek Jankulovski | 14 | 10 | 5 | 4 | 5 | - |
Dida | 13 | 13 | 3 | - | - | - |
Serginho | 11 | 5 | 7 | 6 | 4 | - |
Alberto Paloschi | 7 | 1 | 8 | 6 | 1 | 2 |
Ronaldo | 6 | 4 | 2 | 2 | 4 | 2 |
Dario Simic | 4 | 1 | 9 | 3 | - | - |
Digao | 1 | - | 3 | 1 | - | - |
Valerio Fiore | - | - | 8 | - | - | - |
Catilina Aubameyang | - | - | 1 | - | - | - | 528 | 418 | 172 | 110 | 110 | 66 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .