| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Alessandro Del Piero | 37 | 32 | 5 | 5 | 13 | 21 |
David Trezeguet | 36 | 35 | 1 | 1 | 7 | 20 |
Gianluigi Buffon | 34 | 34 | - | - | 1 | - |
Nicola Legrottaglie | 33 | 31 | 2 | 2 | 2 | 3 |
Cristian Molinaro | 31 | 30 | 2 | 1 | 1 | - |
Pavel Nedved | 31 | 28 | 3 | 3 | 11 | 2 |
Antonio Nocerino | 31 | 23 | 10 | 8 | 4 | - |
Giorgio Chiellini | 30 | 30 | - | - | - | 3 |
Cristiano Zanetti | 26 | 26 | 1 | - | 5 | - |
Hasan Salihamidzic | 26 | 21 | 8 | 5 | 10 | 4 |
Raffaele Palladino | 26 | 14 | 17 | 12 | 8 | 2 |
Zdenek Grygera | 24 | 22 | 5 | 2 | 5 | 1 |
Vincenzo Iaquinta | 24 | 9 | 16 | 15 | 5 | 8 |
Mauro Camoranesi | 22 | 18 | 5 | 4 | 9 | 5 |
Tiago | 20 | 10 | 13 | 10 | 5 | - |
Jonathan Zebina | 16 | 14 | 3 | 2 | 1 | - |
Mohamed Sissoko | 15 | 12 | 3 | 3 | 2 | 1 |
Marco Marchionni | 11 | 1 | 15 | 10 | 1 | 1 |
Sergio Almiron | 9 | 5 | 4 | 4 | 3 | - |
Domenico Criscito | 8 | 8 | 1 | - | 2 | - |
Alessandro Birindelli | 7 | 4 | 8 | 3 | 1 | - |
Emanuele Belardi | 5 | 4 | 11 | 1 | - | - |
Guglielmo Stendardo | 5 | 3 | 4 | 2 | - | - |
Jorge Andrade | 4 | 4 | - | - | 1 | - |
Luca Castiglia | 2 | - | 2 | 2 | - | - |
Cristian Pasquato | 1 | - | 2 | 1 | - | - |
Ruben Olivera | 1 | - | 2 | 1 | - | - |
Oussama Essabr | - | - | 1 | - | - | - |
Lorenzo Ariaudo | - | - | 1 | - | - | - |
Jess Vanstrattan | - | - | 1 | - | - | - | 515 | 418 | 146 | 97 | 97 | 71 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .