| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Tommaso Rocchi | 36 | 31 | 5 | 5 | 11 | 14 |
Cristian Ledesma | 32 | 31 | 1 | 1 | 1 | 3 |
Emilson Cribari | 32 | 30 | 3 | 2 | - | - |
Goran Pandev | 31 | 30 | 2 | 1 | 14 | 14 |
Marco Ballotta | 29 | 29 | 2 | - | - | - |
Gaby Mudingayi | 28 | 21 | 7 | 7 | 5 | - |
Massimo Mutarelli | 24 | 22 | 2 | 2 | 4 | 2 |
Stefano Mauri | 24 | 18 | 7 | 6 | 9 | 3 |
Aleksandar Kolarov | 24 | 17 | 11 | 7 | 2 | 1 |
Lorenzo De Silvestri | 24 | 17 | 11 | 7 | 5 | - |
Valon Behrami | 22 | 21 | 1 | 1 | 7 | 1 |
Christian Manfredini | 21 | 15 | 14 | 6 | 8 | - |
Mourad Meghni | 20 | 7 | 12 | 13 | 8 | - |
Sebastiano Siviglia | 18 | 18 | - | - | - | 1 |
Luciano Zauri | 18 | 17 | 1 | 1 | - | - |
Igli Tare | 18 | 4 | 17 | 14 | 1 | 1 |
Rolando Bianchi | 15 | 9 | 8 | 6 | 7 | 4 |
Ayodele Stephen Makinwa | 15 | 6 | 10 | 9 | 3 | - |
Guglielmo Stendardo | 13 | 13 | 2 | - | 3 | - |
Ousmane Dabo | 12 | 10 | 4 | 2 | 8 | - |
Lionel Scaloni | 12 | 7 | 6 | 5 | 3 | - |
Stefan Radu | 11 | 11 | - | - | 2 | - |
David Rozehnal | 10 | 7 | 6 | 3 | 1 | - |
Fernando Muslera | 9 | 9 | 11 | - | - | - |
Roberto Baronio | 8 | 6 | 8 | 2 | 2 | - |
Fabio Vignaroli | 8 | 3 | 7 | 5 | 2 | - |
Fabio Firmani | 7 | 5 | 4 | 2 | 1 | 3 |
Simone Del Nero | 5 | 2 | 5 | 3 | 2 | - |
Ivan Artipolo | 2 | 1 | 2 | 1 | 1 | - |
Modibo Diakite | 1 | 1 | - | - | 1 | - |
Tommaso Berni | - | - | 2 | - | - | - | 529 | 418 | 171 | 111 | 111 | 47 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .