| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Cristian Zaccardo | 35 | 32 | 3 | 3 | 2 | 1 |
Amauri | 34 | 34 | - | - | 2 | 15 |
Andrea Barzagli | 34 | 33 | 2 | 1 | - | - |
Fabio Simplicio | 32 | 30 | 3 | 2 | 11 | 4 |
Roberto Guana | 32 | 27 | 7 | 5 | 7 | - |
Edinson Cavani | 32 | 17 | 17 | 15 | 11 | 5 |
Alberto Fontana | 31 | 31 | 4 | - | 2 | - |
Giulio Migliaccio | 31 | 27 | 6 | 4 | 5 | - |
Fabio Caserta | 26 | 22 | 5 | 4 | 12 | 1 |
Mattia Cassani | 26 | 18 | 10 | 8 | 5 | 1 |
Bosko Jankovic | 26 | 14 | 15 | 12 | 9 | 2 |
Marco Bresciano | 26 | 12 | 16 | 14 | 7 | 1 |
Giuseppe Biava | 24 | 23 | 5 | 1 | 2 | - |
Leandro Rinaudo | 22 | 20 | 6 | 2 | 2 | 3 |
Fabrizio Miccoli | 22 | 19 | 6 | 3 | 10 | 8 |
Giovanni Tedesco | 17 | 7 | 19 | 10 | 5 | 2 |
Federico Balzaretti | 16 | 16 | - | - | 1 | - |
Aimo Diana | 15 | 12 | 4 | 3 | 2 | 1 |
Ciro Capuano | 13 | 11 | 3 | 2 | 5 | - |
Federico Agliardi | 9 | 7 | 13 | 2 | - | - |
Franco Brienza | 8 | 3 | 9 | 5 | 2 | 1 |
Marco Pisano | 6 | 3 | 4 | 3 | 1 | - |
Edgar Cani | 1 | - | 3 | 1 | - | - |
Paolo Carbonaro | 1 | - | 1 | 1 | - | - |
Luca Di Matteo | 1 | - | 5 | 1 | - | - |
Alberto Cossentino | 1 | - | 5 | 1 | - | - |
Samir Ujkani | - | - | 1 | - | - | - |
Samuele Romeo | - | - | 1 | - | - | - | 521 | 418 | 173 | 103 | 103 | 45 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .