| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Simon Davies | 37 | 36 | 1 | 1 | 2 | 5 |
Clint Dempsey | 36 | 29 | 8 | 7 | 9 | 6 |
Paul Konchesky | 33 | 33 | - | - | - | - |
Danny Murphy | 33 | 28 | 5 | 5 | 9 | 5 |
Aaron Hughes | 30 | 29 | 1 | 1 | 1 | - |
David Healy | 30 | 15 | 18 | 15 | 13 | 4 |
Diomansy Kamara | 28 | 17 | 13 | 11 | 11 | 5 |
Antti Niemi | 22 | 22 | 3 | - | - | - |
Steven Davis | 22 | 22 | - | - | 6 | - |
Carlos Bocanegra | 22 | 18 | 19 | 4 | 1 | 1 |
Hameur Bouazza | 20 | 15 | 5 | 5 | 11 | 1 |
Chris Baird | 18 | 17 | 5 | 1 | 2 | - |
Jimmy Bullard | 17 | 15 | 2 | 2 | 4 | 2 |
Brian McBride | 17 | 14 | 3 | 3 | 5 | 4 |
Brede Hangeland | 15 | 15 | - | - | - | - |
Alexei Smertin | 15 | 11 | 9 | 4 | 5 | 1 |
Paul Stalteri | 13 | 13 | - | - | 2 | - |
Dejan Stefanovic | 13 | 13 | 3 | - | - | - |
Kasey Keller | 13 | 13 | 7 | - | - | - |
Leon Andreasen | 13 | 9 | 5 | 4 | 2 | - |
Ki-Hyeon Seol | 12 | 4 | 12 | 8 | 4 | - |
Shefki Kuqi | 10 | 3 | 10 | 7 | - | - |
Moritz Volz | 9 | 5 | 11 | 4 | 4 | - |
Elliot Omozusi | 8 | 8 | 2 | - | 1 | - |
Erik Nevland | 8 | 2 | 7 | 6 | 2 | 2 |
Eddie Johnson | 6 | 4 | 2 | 2 | 1 | - |
Zatyiah Knight | 4 | 4 | - | - | 1 | - |
Tony Warner | 3 | 3 | 24 | - | - | - |
Papa Bouba Diop | 2 | - | 4 | 2 | - | - |
Collins John | 2 | - | 2 | 2 | - | - |
Nathan Ashton | 1 | 1 | 1 | - | - | - |
Ian Pearce | 1 | - | 1 | 1 | - | - |
Philippe Christanval | 1 | - | 1 | 1 | - | - |
Adrian Leijer | - | - | 3 | - | - | - |
Ricardo Batista | - | - | 3 | - | - | - | 514 | 418 | 190 | 96 | 96 | 36 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .