| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Wes Brown | 36 | 34 | 2 | 2 | 7 | 1 |
Rio Ferdinand | 35 | 35 | - | - | 5 | 2 |
Carlos Tevez | 34 | 31 | 5 | 3 | 12 | 14 |
Cristiano Ronaldo | 34 | 31 | 3 | 3 | 4 | 31 |
Patrice Evra | 33 | 33 | 2 | - | 5 | - |
Nemanja Vidic | 32 | 32 | - | - | 5 | 1 |
Ryan Giggs | 31 | 26 | 5 | 5 | 9 | 3 |
Michael Carrick | 31 | 24 | 8 | 7 | 4 | 2 |
Edwin van der Sar | 29 | 29 | - | - | 1 | - |
John O'Shea | 28 | 10 | 26 | 18 | 3 | - |
Wayne Rooney | 27 | 25 | 2 | 2 | 5 | 12 |
Nani | 26 | 16 | 14 | 10 | 4 | 3 |
Paul Scholes | 24 | 22 | 2 | 2 | 7 | 1 |
Anderson | 24 | 16 | 12 | 8 | 12 | - |
Owen Hargreaves | 23 | 16 | 9 | 7 | 6 | 2 |
Louis Saha | 17 | 6 | 13 | 11 | 3 | 5 |
Darren Fletcher | 16 | 5 | 16 | 11 | - | - |
Ji Sung Park | 12 | 8 | 6 | 4 | 6 | 1 |
Tomasz Kuszczak | 9 | 8 | 29 | 1 | - | - |
Gerard Pique | 8 | 5 | 12 | 3 | 1 | - |
Chris Eagles | 4 | 1 | 5 | 3 | 1 | - |
Mikael Silvestre | 3 | 3 | 2 | - | 2 | - |
Danny Simpson | 3 | 1 | 5 | 2 | 1 | - |
Ben Foster | 1 | 1 | 3 | - | - | - |
Fraizer Campbell | 1 | - | 1 | 1 | - | - |
Tom Heaton | - | - | 6 | - | - | - |
FangZhou Dong | - | - | 1 | - | - | - |
Darron Gibson | - | - | 1 | - | - | - | 521 | 418 | 190 | 103 | 103 | 78 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .