| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Steed Malbranque | 37 | 35 | 2 | 2 | 13 | 4 |
Dimitar Berbatov | 36 | 33 | 3 | 3 | 6 | 15 |
Robbie Keane | 36 | 32 | 4 | 4 | 16 | 15 |
Pascal Chimbonda | 32 | 31 | 4 | 1 | 3 | 2 |
Jermaine Jenas | 29 | 28 | 1 | 1 | 2 | 4 |
Aaron Lennon | 29 | 25 | 5 | 4 | 10 | 2 |
Didier Zokora | 28 | 25 | 5 | 3 | 3 | - |
Tom Huddlestone | 28 | 18 | 13 | 10 | 1 | 3 |
Michael Dawson | 27 | 26 | 2 | 1 | 4 | 1 |
Darren Bent | 27 | 11 | 17 | 16 | 7 | 6 |
Paul Robinson | 25 | 25 | 8 | - | - | - |
Younes Kaboul | 21 | 19 | 3 | 2 | 4 | 3 |
Jermain Defoe | 19 | 3 | 18 | 16 | 2 | 4 |
Young-pyo Lee | 18 | 17 | 5 | 1 | 2 | - |
Jamie O'Hara | 17 | 9 | 9 | 8 | 3 | 1 |
Teemu Tainio | 16 | 6 | 17 | 10 | 5 | - |
Alan Hutton | 14 | 14 | - | - | 1 | - |
Radek Cerny | 13 | 13 | 25 | - | - | - |
Kevin-Prince Boateng | 13 | 7 | 9 | 6 | 6 | - |
Jonathan Woodgate | 12 | 12 | - | - | 1 | 1 |
Gareth Bale | 8 | 8 | - | - | 3 | 2 |
Gilberto | 6 | 3 | 4 | 3 | - | 1 |
Adel Taarabt | 6 | - | 11 | 6 | - | - |
Ricardo Rocha | 5 | 4 | 6 | 1 | 1 | - |
Anthony Gardner | 4 | 4 | 2 | - | - | 1 |
Ledley King | 4 | 4 | - | - | 3 | - |
Paul Stalteri | 3 | 3 | 5 | - | 2 | - |
Wayne Routledge | 2 | 1 | 1 | 1 | 1 | - |
Chris Gunter | 2 | 1 | 3 | 1 | 1 | - |
Benoit Assou-Ekotto | 1 | 1 | - | - | - | - |
Ben Alnwick | - | - | 1 | - | - | - |
Danny Rose | - | - | 1 | - | - | - |
Troy Archibald-Henville | - | - | 2 | - | - | - |
Tommy Forecast | - | - | 4 | - | - | - | 518 | 418 | 190 | 100 | 100 | 65 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .