| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Francesc Fabregas | 38 | 34 | 4 | 4 | 3 | 2 |
Jens Lehmann | 36 | 36 | - | - | - | - |
Kolo Toure | 35 | 35 | - | - | - | 3 |
Gilberto Silva | 34 | 34 | - | - | 3 | 10 |
Aliaksandr Hleb | 33 | 27 | 7 | 6 | 15 | 2 |
Emmanuel Adebayor | 29 | 21 | 10 | 8 | 7 | 8 |
Gael Clichy | 27 | 26 | 2 | 1 | - | - |
Tomas Rosicky | 26 | 22 | 4 | 4 | 13 | 3 |
Emmanuel Eboue | 24 | 23 | 1 | 1 | 4 | - |
Julio Baptista | 24 | 11 | 16 | 13 | 6 | 3 |
Justin Hoyte | 22 | 18 | 10 | 4 | 6 | 1 |
Robin van Persie | 22 | 17 | 5 | 5 | 9 | 11 |
William Gallas | 21 | 21 | - | - | 1 | 3 |
Johan Djourou | 21 | 18 | 9 | 3 | 3 | - |
Mathieu Flamini | 20 | 9 | 14 | 11 | 3 | 3 |
Fredrik Ljungberg | 18 | 16 | 2 | 2 | 9 | - |
Thierry Henry | 17 | 16 | 1 | 1 | 1 | 10 |
Theo Walcott | 16 | 5 | 16 | 11 | 4 | - |
Philippe Senderos | 14 | 9 | 18 | 5 | - | - |
Abou Diaby | 12 | 9 | 3 | 3 | 4 | 1 |
Jeremie Aliadiere | 11 | 4 | 8 | 7 | 3 | - |
Denilson | 10 | 4 | 10 | 6 | 1 | - |
Alex Song | 2 | 1 | 4 | 1 | 1 | - |
Manuel Almunia | 1 | 1 | 35 | - | - | - |
Mart Poom | 1 | 1 | 2 | - | - | - |
Pascal Cygan | - | - | 2 | - | - | - |
Etame-Mayer Lauren | - | - | 1 | - | - | - |
Mark Randall | - | - | 1 | - | - | - |
Matthew Connolly | - | - | 1 | - | - | - |
Joe O'Cearuill | - | - | 1 | - | - | - |
Kieran Gibbs | - | - | 1 | - | - | - |
Vito Mannone | - | - | 1 | - | - | - |
Armand Traore | - | - | 1 | - | - | - | 514 | 418 | 190 | 96 | 96 | 60 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .