| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Wayne Rooney | 35 | 33 | 2 | 2 | 6 | 14 |
Cristiano Ronaldo | 34 | 31 | 4 | 3 | 11 | 17 |
Rio Ferdinand | 33 | 33 | 1 | - | 1 | 1 |
Michael Carrick | 33 | 29 | 5 | 4 | 10 | 3 |
Edwin van der Sar | 32 | 32 | 3 | - | - | - |
John O'Shea | 32 | 16 | 20 | 16 | - | 4 |
Paul Scholes | 30 | 29 | 3 | 1 | 3 | 6 |
Ryan Giggs | 30 | 25 | 6 | 5 | 10 | 4 |
Nemanja Vidic | 25 | 25 | 2 | - | 3 | 3 |
Gary Neville | 24 | 24 | - | - | 4 | - |
Patrice Evra | 24 | 22 | 7 | 2 | 10 | 1 |
Louis Saha | 24 | 18 | 10 | 6 | 6 | 8 |
Darren Fletcher | 24 | 16 | 12 | 8 | 5 | 3 |
Gabriel Heinze | 22 | 17 | 7 | 5 | 4 | - |
Wes Brown | 22 | 17 | 13 | 5 | 1 | - |
Ole-Gunnar Solskjaer | 19 | 9 | 15 | 10 | 3 | 7 |
Kieran Richardson | 15 | 8 | 11 | 7 | 4 | 1 |
Ji Sung Park | 14 | 8 | 8 | 6 | 4 | 5 |
Mikael Silvestre | 14 | 6 | 13 | 8 | 1 | 1 |
Alan Smith | 9 | 6 | 4 | 3 | 4 | - |
Henrik Larsson | 7 | 5 | 2 | 2 | 3 | 1 |
Tomasz Kuszczak | 6 | 6 | 31 | - | - | - |
Chris Eagles | 2 | 1 | 2 | 1 | - | 1 |
FangZhou Dong | 1 | 1 | - | - | 1 | - |
Kieran Lee | 1 | 1 | 1 | - | - | - |
Giuseppe Rossi | - | - | 2 | - | - | - |
Tom Heaton | - | - | 4 | - | - | - |
Ritchie Jones | - | - | 1 | - | - | - |
Craig Cathcart | - | - | 1 | - | - | - | 512 | 418 | 190 | 94 | 94 | 80 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .