| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Alan Smith | 6 | 6 | - | - | 1 | - |
John O'Shea | 6 | 6 | - | - | 1 | - |
Rio Ferdinand | 6 | 6 | - | - | - | - |
Cristiano Ronaldo | 6 | 6 | - | - | 3 | - |
Ruud van Nistelrooy | 6 | 6 | - | - | 1 | 1 |
Edwin van der Sar | 6 | 6 | - | - | - | - |
Paul Scholes | 5 | 5 | - | - | - | 1 |
Darren Fletcher | 5 | 5 | 1 | - | 1 | - |
Mikael Silvestre | 5 | 5 | - | - | - | - |
Ji Sung Park | 5 | - | 6 | 5 | - | - |
Wayne Rooney | 4 | 4 | - | - | - | - |
Ryan Giggs | 4 | 3 | 1 | 1 | 2 | 1 |
Kieran Richardson | 4 | 2 | 3 | 2 | 1 | - |
Philip Bardsley | 2 | 2 | 3 | - | - | - |
Wes Brown | 2 | 2 | 1 | - | 1 | - |
Gary Neville | 2 | 1 | 1 | 1 | - | - |
Louis Saha | 2 | - | 2 | 2 | - | - |
Gabriel Heinze | 1 | 1 | - | - | 1 | - |
Giuseppe Rossi | 1 | - | 4 | 1 | - | - |
Liam Miller | - | - | 4 | - | - | - |
Gerard Pique | - | - | 5 | - | - | - |
Ritchie Jones | - | - | 1 | - | - | - |
Tim Howard | - | - | 6 | - | - | - |
Lee Martin | - | - | 2 | - | - | - |
Sylvan Ebanks-Blake | - | - | 2 | - | - | - | 78 | 66 | 42 | 12 | 12 | 3 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .