| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Mikael Silvestre | 34 | 33 | 1 | 1 | 3 | - |
John O'Shea | 33 | 32 | 5 | 1 | 5 | 2 |
Ryan Giggs | 33 | 29 | 6 | 4 | 9 | 7 |
Tim Howard | 32 | 32 | 6 | - | - | - |
Ruud van Nistelrooy | 32 | 31 | 2 | 1 | 4 | 20 |
Phil Neville | 31 | 29 | 4 | 2 | 9 | - |
Gary Neville | 30 | 30 | - | - | 1 | 2 |
Cristiano Ronaldo | 29 | 15 | 18 | 14 | 6 | 4 |
Roy Keane | 28 | 25 | 3 | 3 | 5 | 3 |
Paul Scholes | 28 | 24 | 4 | 4 | 3 | 9 |
Diego Forlan | 24 | 10 | 20 | 14 | 4 | 4 |
Quinton Fortune | 23 | 18 | 7 | 5 | 5 | - |
Darren Fletcher | 22 | 17 | 11 | 5 | 7 | - |
Nicky Butt | 21 | 12 | 21 | 9 | 5 | 1 |
Rio Ferdinand | 20 | 20 | - | - | 1 | - |
Wes Brown | 17 | 15 | 3 | 2 | 1 | - |
Eric Djemba-Djemba | 15 | 10 | 11 | 5 | 7 | - |
David Bellion | 14 | 4 | 14 | 10 | 2 | 2 |
Ole-Gunnar Solskjaer | 13 | 7 | 8 | 6 | 5 | - |
Kleberson | 12 | 10 | 8 | 2 | 6 | 2 |
Louis Saha | 12 | 9 | 3 | 3 | 3 | 7 |
Roy Carroll | 6 | 6 | 32 | - | - | - |
Danny Pugh | - | - | 1 | - | - | - |
Mark Lynch | - | - | 1 | - | - | - |
Jonathan Spector | - | - | 1 | - | - | - | 509 | 418 | 190 | 91 | 91 | 63 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .