| 5 | Philippe Mexes | Group Stage | UEFA Champions League 12/13 |
| 5 | Gennaro Gattuso | Second Group Stage | UEFA Champions League 02/03 |
| 4 | Fikayo Tomori | Group Stage | UEFA Champions League 22/23 |
| 4 | Rade Krunic | Group Stage | UEFA Champions League 22/23 |
| 4 | Yunus Musah | Group Section | UEFA Champions League 23/24 |
| 4 | Massimo Ambrosini | Group Stage | UEFA Champions League 11/12 |
| 4 | Gennaro Gattuso | Group Stage | UEFA Champions League 05/06 |
| 4 | Gennaro Gattuso | First Group Stage | UEFA Champions League 00/01 |
| 3 | Sandro Tonali | Group Stage | UEFA Champions League 22/23 |
| 3 | Mario Balotelli | Group Stage | UEFA Champions League 13/14 |
| 3 | Sulley Muntari | Group Stage | UEFA Champions League 13/14 |
| 3 | Mathieu Flamini | Group Stage | UEFA Champions League 12/13 |
| 3 | Antonio Nocerino | Group Stage | UEFA Champions League 11/12 |
| 3 | Alessandro Nesta | Group Stage | UEFA Champions League 11/12 |
| 3 | Mark van Bommel | Group Stage | UEFA Champions League 11/12 |
| 3 | Gennaro Gattuso | Group Stage | UEFA Champions League 10/11 |
| 3 | Mathieu Flamini | Group Stage | UEFA Champions League 10/11 |
| 3 | Ronaldinho Gaucho | Group Stage | UEFA Champions League 09/10 |
| 3 | Gianluca Zambrotta | Group Stage | UEFA Champions League 09/10 |
| 3 | Massimo Ambrosini | Group Stage | UEFA Champions League 07/08 |
| 3 | Gennaro Gattuso | Group Stage | UEFA Champions League 06/07 |
| 3 | Alberto Gilardino | Group Stage | UEFA Champions League 06/07 |
| 3 | Gennaro Gattuso | Group Stage | UEFA Champions League 04/05 |
| 3 | Alessandro Nesta | Group Stage | UEFA Champions League 04/05 |
| 3 | Massimo Ambrosini | First Group Stage | UEFA Champions League 02/03 |
| 3 | Leonardo | First Group Stage | UEFA Champions League 99/00 |
| 3 | Alessandro Costacurta | First Group Stage | UEFA Champions League 99/00 |
| 3 | Paolo Maldini | First Group Stage | UEFA Champions League 99/00 |
| 3 | Jose Chamot | First Group Stage | UEFA Champions League 00/01 |
| 3 | Federico Giunti | Second Group Stage | UEFA Champions League 00/01 |
| 3 | Demetrio Albertini | First Group Stage | UEFA Champions League 00/01 |
| 3 | Thomas Helveg | Second Group Stage | UEFA Champions League 00/01 |
| 2 | Davide Calabria | Group Stage | UEFA Champions League 22/23 |
| 2 | Fode Ballo | Group Stage | UEFA Champions League 22/23 |
| 2 | Theo Hernandez | Round of 16 | UEFA Champions League 22/23 |
| 2 | Malick Thiaw | Round of 16 | UEFA Champions League 22/23 |
| 2 | Olivier Giroud | Group Stage | UEFA Champions League 21/22 |
| 2 | Theo Hernandez | Group Stage | UEFA Champions League 21/22 |
| 2 | Fikayo Tomori | Group Stage | UEFA Champions League 21/22 |
| 2 | Fikayo Tomori | Group Section | UEFA Champions League 23/24 |
| 2 | Rade Krunic | Group Section | UEFA Champions League 23/24 |
| 2 | Daniele Bonera | Round of 16 | UEFA Champions League 13/14 |
| 2 | Nigel De Jong | Group Stage | UEFA Champions League 13/14 |
| 2 | Adil Rami | Round of 16 | UEFA Champions League 13/14 |
| 2 | Ignazio Abate | Group Stage | UEFA Champions League 13/14 |
| 2 | Daniele Bonera | Group Stage | UEFA Champions League 12/13 |
| 2 | Riccardo Montolivo | Group Stage | UEFA Champions League 12/13 |
| 2 | Philippe Mexes | Round of 16 | UEFA Champions League 11/12 |
| 2 | Clarence Seedorf | Quarter-finals | UEFA Champions League 11/12 |
| 2 | Luca Antonini | Round of 16 | UEFA Champions League 11/12 |
| 2 | Kevin-Prince Boateng | Group Stage | UEFA Champions League 10/11 |
| 2 | Gianluca Zambrotta | Group Stage | UEFA Champions League 10/11 |
| 2 | Luca Antonini | Group Stage | UEFA Champions League 10/11 |
| 2 | Mathieu Flamini | Group Stage | UEFA Champions League 09/10 |
| 2 | Ignazio Abate | Group Stage | UEFA Champions League 09/10 |
| 2 | Gianluigi Lentini | Final | UEFA Champions League 92/93 |
| 2 | Stefano Eranio | Group Stage | UEFA Champions League 92/93 |
| 2 | Franco Baresi | Group Stage | UEFA Champions League 92/93 |
| 2 | Demetrio Albertini | Final | UEFA Champions League 93/94 |
| 2 | Daniele Massaro | Final | UEFA Champions League 93/94 |
