| MD | Players | Clubs | Nationality | DOB | A(D) |
|---|---|---|---|---|---|
| 23-Jul-2021 |  Obed Vargas | Seattle Sounders | United States | 05-Aug-2005 | 15(352) |
| 23-Jul-2021 | Reed Baker-Whiting | Seattle Sounders | United States | 31-Mar-2005 | 16(114) |
| 17-Apr-2021 | Jahkeele Marshall-Rutty | Toronto FC | Canada | 16-Jun-2004 | 16(305) |
| 18-Jul-2021 | Dantouma Toure | Colorado Rapids | United States | 12-Jun-2004 | 17(36) |
| 02-May-2021 | Quinn Sullivan | Philadelphia Union | United States | 27-Mar-2004 | 17(36) |
| 05-Aug-2021 | Gabriel Slonina | Chicago Fire | United States | 15-May-2004 | 17(82) |
| 02-May-2021 | Patrick Weah | Minnesota United | United States | 05-Dec-2003 | 17(149) |
| 02-May-2021 | Edison Azcona | Inter Miami CF | Dominican Republic | 21-Nov-2003 | 17(163) |
| 25-Apr-2021 | Moses Nyeman | DC United | Liberia | 05-Nov-2003 | 17(172) |
| 17-Apr-2021 | Cade Cowell | San Jose Earthquakes | United States | 14-Oct-2003 | 17(186) |
| 03-May-2021 | Kamron Habibullah | Vancouver Whitecaps | Canada | 23-Oct-2003 | 17(193) |
| 24-Jun-2021 | Justin Che | FC Dallas | United States | 18-Nov-2003 | 17(219) |
| 09-Aug-2021 | Rida Zouhir | Montreal Impact | Canada | 23-Nov-2003 | 17(260) |
| 31-May-2021 | Paxten Aaronson | Philadelphia Union | United States | 26-Aug-2003 | 17(279) |
| 25-Apr-2021 | Jack McGlynn | Philadelphia Union | United States | 07-Jul-2003 | 17(293) |
| 01-May-2021 | Brian Gutierrez | Chicago Fire | United States | 17-Jun-2003 | 17(319) |
| 18-Apr-2021 | Caden Clark | New York Red Bulls | United States | 27-May-2003 | 17(327) |
| 25-Jul-2021 | Arquimides Ordonez | Cincinnati | United States | 05-Aug-2003 | 17(355) |
| 03-May-2021 | Daniel Leyva | Seattle Sounders | United States | 05-May-2003 | 17(364) |
| 17-May-2021 | Kevin Paredes | DC United | Peru | 07-May-2003 | 18(11) |
| 02-May-2021 | Dante Sealy | FC Dallas | United States | 07-Apr-2003 | 18(26) |
| 18-Apr-2021 | Wikelman Carmona | New York Red Bulls | Venezuela | 24-Feb-2003 | 18(54) |
MD = Match date,
DOB = Date Of Birth,
A(D) = Age(Days).