| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Lorenzo Montipo | Hellas Verona | Italy | 61 | |
| 2 | Bartlomiej Dragowski | Spezia Calcio | Poland | 58 | |
| 3 | Andrea Consigli | Sassuolo | Italy | 56 | |
| 4 | Michele Di Gregorio | Monza | Italy | 51 | |
| 5 | Lukasz Skorupski | Bologna | Poland | 50 | |
| 6 | Marco Silvestri | Udinese | Italy | 49 | |
| 7 | Wladimiro Falcone | Lecce | Italy | 48 | |
| 8 | Marco Carnesecchi | Cremonese | Italy | 47 | |
| 9 | Vanja Milinkovic-Savic | Torino | Serbia | 42 | |
| 10 | Guglielmo Vicario | Empoli | Italy | 42 | |
| 11 | Pietro Terracciano | Fiorentina | Italy | 40 | |
| 12 | Emil Audero | Sampdoria | Italy | 39 | |
| 13 | Rui Patricio | AS Roma | Portugal | 35 | |
| 14 | Guillermo Ochoa | Salernitana | Mexico | 34 | |
| 15 | Ivan Provedel | SS Lazio | Italy | 29 | |
| 16 | Luigi Sepe | Salernitana | Italy | 28 | |
| 17 | Juan Musso | Atalanta | Argentina | 28 | |
| 18 | Alex Meret | Napoli | Italy | 26 | |
| 19 | Wojciech Szczesny | Juventus | Poland | 26 | |
| 20 | Andre Onana | Internazionale | Cameroon | 25 |
GC = Goals conceded