| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Jonathan Bond | Los Angeles Galaxy | England | 39 | |
| 2 | Alex Bono | Toronto FC | United States | 34 | |
| 3 | JT Marcinkowski | San Jose Earthquakes | United States | 34 | |
| 4 | Marko Maric | Houston Dynamo | Croatia | 33 | |
| 5 | Bobby Shuttleworth | Chicago Fire | United States | 32 | |
| 6 | Eloy Room | Columbus Crew | Curacao | 30 | |
| 7 | Kenneth Vermeer | Cincinnati | Netherlands | 30 | |
| 8 | Jimmy Maurer | FC Dallas | United States | 30 | |
| 9 | Brad Stuver | Austin FC | United States | 29 | |
| 10 | Carlos Coronel | New York Red Bulls | Brazil | 26 | |
| 11 | Maxime Crepeau | Vancouver Whitecaps | Canada | 25 | |
| 12 | Joe Willis | Nashville SC | United States | 23 | |
| 13 | Brad Guzan | Atlanta United | United States | 23 | |
| 14 | Matt Turner | New England Revolution | United States | 23 | |
| 15 | Tomas Romero | Los Angeles FC | El Salvador | 22 | |
| 16 | William Yarbrough | Colorado Rapids | United States | 22 | |
| 17 | Andre Blake | Philadelphia Union | Jamaica | 19 | |
| 18 | David Ochoa | Real Salt Lake | United States | 17 | |
| 19 | Steve Clark | Portland Timbers | United States | 17 | |
| 20 | John McCarthy | Inter Miami CF | United States | 17 |
GC = Goals conceded