| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Bobby Shuttleworth | Minnesota United | United States | 61 | |
| 2 | Joe Bendik | Orlando City | United States | 52 | |
| 3 | Cody Cropper | New England Revolution | United States | 51 | |
| 4 | Luis Robles | New York Red Bulls | United States | 50 | |
| 5 | Evan Bush | Montreal Impact | United States | 50 | |
| 6 | Zack Steffen | Columbus Crew | United States | 49 | |
| 7 | David Ousted | Vancouver Whitecaps | Denmark | 42 | |
| 8 | Jesse Gonzalez | FC Dallas | United States | 40 | |
| 9 | Tim Howard | Colorado Rapids | United States | 39 | |
| 10 | Sean Johnson | New York City | United States | 39 | |
| 11 | Bill Hamid | DC United | United States | 38 | |
| 12 | Stefan Frei | Seattle Sounders | Switzerland | 37 | |
| 13 | David Bingham | San Jose Earthquakes | United States | 35 | |
| 14 | Alex Bono | Toronto FC | United States | 35 | |
| 15 | Andre Blake | Philadelphia Union | Jamaica | 35 | |
| 16 | Jake Gleeson | Portland Timbers | New Zealand | 34 | |
| 17 | Nick Rimando | Real Salt Lake | United States | 34 | |
| 18 | Clement Diop | Los Angeles Galaxy | France | 33 | |
| 19 | Tyler Deric | Houston Dynamo | United States | 33 | |
| 20 | Matt Lampson | Chicago Fire | United States | 33 |
GC = Goals conceded