| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Joe Bendik | Orlando City | United States | 62 | |
| 2 | Josh Saunders | New York City | United States | 56 | |
| 3 | David Ousted | Vancouver Whitecaps | Denmark | 55 | |
| 4 | Steve Clark | Columbus Crew | United States | 53 | |
| 5 | Evan Bush | Montreal Impact | United States | 52 | |
| 6 | Andre Blake | Philadelphia Union | Jamaica | 52 | |
| 7 | Luis Robles | New York Red Bulls | United States | 46 | |
| 8 | Nick Rimando | Real Salt Lake | United States | 42 | |
| 9 | Stefan Frei | Seattle Sounders | Switzerland | 42 | |
| 10 | David Bingham | San Jose Earthquakes | United States | 40 | |
| 11 | Jake Gleeson | Portland Timbers | New Zealand | 39 | |
| 12 | Sean Johnson | Chicago Fire | United States | 39 | |
| 13 | Bobby Shuttleworth | New England Revolution | United States | 38 | |
| 14 | Joe Willis | Houston Dynamo | United States | 36 | |
| 15 | Brian Rowe | Los Angeles Galaxy | United States | 35 | |
| 16 | Tim Melia | Sporting Kansas City | United States | 30 | |
| 17 | Chris Seitz | FC Dallas | United States | 30 | |
| 18 | Bill Hamid | DC United | United States | 25 | |
| 19 | Clint Irwin | Toronto FC | United States | 25 | |
| 20 | Tim Howard | Colorado Rapids | United States | 19 |
GC = Goals conceded