| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Antonio Rosati | Lecce | Italy | 64 | |
| 2 | Salvatore Sirigu | Palermo | Italy | 60 | |
| 3 | Jean Francois Gillet | Bari | Belgium | 53 | |
| 4 | Mariano Andujar | Catania | Argentina | 51 | |
| 5 | Michael Agazzi | Cagliari | Italy | 51 | |
| 6 | Emiliano Viviano | Bologna | Italy | 49 | |
| 7 | Eduardo | Genoa | Portugal | 48 | |
| 8 | Antonio Mirante | Parma | Italy | 46 | |
| 9 | Francesco Antonioli | AC Cesena | Italy | 46 | |
| 10 | Gianluca Curci | Sampdoria | Italy | 43 | |
| 11 | Fernando Muslera | SS Lazio | Uruguay | 41 | |
| 12 | Morgan De Sanctis | Napoli | Italy | 40 | |
| 13 | Samir Handanovic | Udinese | Slovenia | 38 | |
| 14 | Stefano Sorrentino | Chievo | Italy | 36 | |
| 15 | Julio Sergio | AS Roma | Brazil | 34 | |
| 16 | Marco Storari | Juventus | Italy | 33 | |
| 17 | Artur Boruc | Fiorentina | Poland | 31 | |
| 18 | Michele Arcari | Brescia | Italy | 29 | |
| 19 | Julio Cesar | Internazionale | Brazil | 23 | |
| 20 | Matteo Sereni | Brescia | Italy | 22 |
GC = Goals conceded