| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Robert Green | West Ham United | England | 70 | |
| 2 | Brad Friedel | Aston Villa | United States | 62 | |
| 3 | Scott Carson | West Bromwich Albion | England | 61 | |
| 4 | Paul Robinson | Blackburn Rovers | England | 59 | |
| 5 | Ben Foster | Birmingham City | England | 58 | |
| 6 | Ali Al Habsi | Wigan Athletic | Oman | 53 | |
| 7 | Jussi Jaaskelainen | Bolton Wanderers | Finland | 51 | |
| 8 | Tim Howard | Everton | United States | 46 | |
| 9 | Pepe Reina | Liverpool | Spain | 45 | |
| 10 | Wayne Hennessey | Wolverhampton Wanderers | Wales | 42 | |
| 11 | Heurelho Gomes | Tottenham Hotspur | Brazil | 41 | |
| 12 | Simon Mignolet | Sunderland | Belgium | 39 | |
| 13 | Richard Kingson | Blackpool | Ghana | 38 | |
| 14 | Joe Hart | Manchester City | England | 37 | |
| 15 | Mark Schwarzer | Fulham | Australia | 36 | |
| 16 | Tim Krul | Newcastle United | Netherlands | 36 | |
| 17 | Matthew Gilks | Blackpool | Scotland | 36 | |
| 18 | Petr Cech | Chelsea | Czech Republic | 34 | |
| 19 | Edwin van der Sar | Manchester United | Netherlands | 33 | |
| 20 | Asmir Begovic | Stoke City | Bosnia and Herzegovina | 32 |
GC = Goals conceded