| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Gianluca Curci | Siena | Italy | 66 | |
| 2 | Samir Handanovic | Udinese | Slovenia | 56 | |
| 3 | Emiliano Viviano | Bologna | Italy | 52 | |
| 4 | Antonio Mirante | Parma | Italy | 51 | |
| 5 | Federico Marchetti | Cagliari | Italy | 50 | |
| 6 | Marco Amelia | Genoa | Italy | 48 | |
| 7 | Jean Francois Gillet | Bari | Belgium | 44 | |
| 8 | Fernando Muslera | SS Lazio | Uruguay | 42 | |
| 9 | Andrea Consigli | Atalanta | Italy | 42 | |
| 10 | Morgan De Sanctis | Napoli | Italy | 42 | |
| 11 | Sebastian Frey | Fiorentina | France | 41 | |
| 12 | Mariano Andujar | Catania | Argentina | 40 | |
| 13 | Stefano Sorrentino | Chievo | Italy | 40 | |
| 14 | Salvatore Sirigu | Palermo | Italy | 39 | |
| 15 | Gianluigi Buffon | Juventus | Italy | 35 | |
| 16 | Julio Cesar | Internazionale | Brazil | 35 | |
| 17 | Alfonso de Lucia | Livorno | Italy | 33 | |
| 18 | Julio Sergio | AS Roma | Brazil | 29 | |
| 19 | Dida | AC Milan | Brazil | 28 | |
| 20 | Rubinho | Palermo | Brazil | 27 |
GC = Goals conceded