| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Scott Carson | West Bromwich Albion | England | 66 | |
| 2 | Shay Given | Newcastle United | Republic of Ireland | 57 | |
| 3 | Paul Robinson | Blackburn Rovers | England | 57 | |
| 4 | David James | Portsmouth | England | 56 | |
| 5 | Brad Friedel | Aston Villa | United States | 54 | |
| 6 | Boaz Myhill | Hull City | Wales | 54 | |
| 7 | Jussi Jaaskelainen | Bolton Wanderers | Finland | 54 | |
| 8 | Thomas Sorensen | Stoke City | Denmark | 48 | |
| 9 | Robert Green | West Ham United | England | 45 | |
| 10 | Heurelho Gomes | Tottenham Hotspur | Brazil | 42 | |
| 11 | Christopher Kirkland | Wigan Athletic | England | 40 | |
| 12 | Tim Howard | Everton | United States | 39 | |
| 13 | Marton Fulop | Sunderland | Hungary | 38 | |
| 14 | Ross Turnbull | Middlesbrough | England | 34 | |
| 15 | Mark Schwarzer | Fulham | Australia | 33 | |
| 16 | Joe Hart | Manchester City | England | 33 | |
| 17 | Pepe Reina | Liverpool | Spain | 31 | |
| 18 | Manuel Almunia | Arsenal | Spain | 30 | |
| 19 | Petr Cech | Chelsea | Czech Republic | 26 | |
| 20 | Brad Jones | Middlesbrough | Australia | 25 |
GC = Goals conceded