| Group F | P | W | D | L | GF | GA | GD | points |
|---|---|---|---|---|---|---|---|---|
 Manchester United | 6 | 3 | 2 | 1 | 11 | 8 | 3 | 11 |
 Villarreal | 6 | 3 | 1 | 2 | 12 | 9 | 3 | 10 |
 Atalanta | 6 | 1 | 3 | 2 | 12 | 13 | -1 | 6 |
 BSC Young Boys | 6 | 1 | 2 | 3 | 7 | 12 | -5 | 5 |
Thursday 9 December 2021 | |||||||
| Atalanta | 2 | - | 3 | Villarreal | 17:00 | STATS» | |
Wednesday 8 December 2021 | |||||||
| Manchester United | 1 | - | 1 | BSC Young Boys | 19:00 | STATS» | |
Tuesday 23 November 2021 | |||||||
| BSC Young Boys | 3 | - | 3 | Atalanta | 19:00 | STATS» | |
| Villarreal | 0 | - | 2 | Manchester United | 16:45 | STATS» | |
Tuesday 2 November 2021 | |||||||
| Atalanta | 2 | - | 2 | Manchester United | 19:00 | STATS» | |
| Villarreal | 2 | - | 0 | BSC Young Boys | 19:00 | STATS» | |
Wednesday 20 October 2021 | |||||||
| Manchester United | 3 | - | 2 | Atalanta | 19:00 | STATS» | |
| BSC Young Boys | 1 | - | 4 | Villarreal | 16:45 | STATS» | |
Wednesday 29 September 2021 | |||||||
| Manchester United | 2 | - | 1 | Villarreal | 19:00 | STATS» | |
| Atalanta | 1 | - | 0 | BSC Young Boys | 16:45 | STATS» | |
Tuesday 14 September 2021 | |||||||
| Villarreal | 2 | - | 2 | Atalanta | 19:00 | STATS» | |
| BSC Young Boys | 2 | - | 1 | Manchester United | 16:45 | STATS» | |