| Group E | P | W | D | L | GF | GA | GD | points |
|---|---|---|---|---|---|---|---|---|
 Barcelona | 6 | 4 | 2 | 0 | 15 | 4 | 11 | 14 |
 Bayer Leverkusen | 6 | 1 | 3 | 2 | 13 | 12 | 1 | 6 |
 AS Roma | 6 | 1 | 3 | 2 | 11 | 16 | -5 | 6 |
 FC BATE Borisov | 6 | 1 | 2 | 3 | 5 | 12 | -7 | 5 |
Wednesday 9 December 2015 | |||||||
| AS Roma | 0 | - | 0 | FC BATE Borisov | 18:45 | STATS» | |
| Bayer Leverkusen | 1 | - | 1 | Barcelona | 18:45 | STATS» | |
Tuesday 24 November 2015 | |||||||
| Barcelona | 6 | - | 1 | AS Roma | 18:45 | STATS» | |
| FC BATE Borisov | 1 | - | 1 | Bayer Leverkusen | 16:00 | STATS» | |
Wednesday 4 November 2015 | |||||||
| AS Roma | 3 | - | 2 | Bayer Leverkusen | 18:45 | STATS» | |
| Barcelona | 3 | - | 0 | FC BATE Borisov | 18:45 | STATS» | |
Tuesday 20 October 2015 | |||||||
| Bayer Leverkusen | 4 | - | 4 | AS Roma | 18:45 | STATS» | |
| FC BATE Borisov | 0 | - | 2 | Barcelona | 18:45 | STATS» | |
Tuesday 29 September 2015 | |||||||
| FC BATE Borisov | 3 | - | 2 | AS Roma | 18:45 | STATS» | |
| Barcelona | 2 | - | 1 | Bayer Leverkusen | 18:45 | STATS» | |
Wednesday 16 September 2015 | |||||||
| AS Roma | 1 | - | 1 | Barcelona | 18:45 | STATS» | |
| Bayer Leverkusen | 4 | - | 1 | FC BATE Borisov | 18:45 | STATS» | |