| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 David de Gea | 38 | 38 | - | - | - | - |
Bruno Fernandes | 36 | 35 | 1 | 1 | 9 | 10 |
Scott McTominay | 30 | 28 | 3 | 2 | 8 | 1 |
Harry Maguire | 30 | 28 | 5 | 2 | 1 | 1 |
Cristiano Ronaldo | 30 | 27 | 3 | 3 | 6 | 18 |
Jadon Sancho | 29 | 20 | 12 | 9 | 9 | 3 |
Fred | 28 | 24 | 7 | 4 | 10 | 4 |
Victor Lindelof | 27 | 25 | 8 | 2 | 1 | - |
Marcus Rashford | 25 | 13 | 15 | 12 | 10 | 4 |
Diogo Dalot | 24 | 19 | 18 | 5 | 1 | - |
Raphael Varane | 23 | 21 | 4 | 2 | - | 1 |
Nemanja Matic | 23 | 16 | 17 | 7 | 9 | - |
Alex Telles | 21 | 18 | 11 | 3 | 2 | - |
Anthony Elanga | 21 | 14 | 10 | 7 | 9 | 2 |
Aaron Wan-Bissaka | 20 | 20 | 10 | - | 1 | - |
Luke Shaw | 20 | 19 | 3 | 1 | 4 | - |
Paul Pogba | 20 | 16 | 4 | 4 | 7 | 1 |
Mason Greenwood | 18 | 16 | 5 | 2 | 12 | 5 |
Jesse Lingard | 16 | 2 | 30 | 14 | 2 | 2 |
Edinson Cavani | 15 | 7 | 8 | 8 | 3 | 2 |
Anthony Martial | 8 | 2 | 11 | 6 | 2 | 1 |
Donny van de Beek | 8 | - | 22 | 8 | - | 1 |
Juan Mata | 7 | 2 | 27 | 5 | 2 | - |
Eric Bailly | 4 | 3 | 18 | 1 | 2 | - |
Phil Jones | 4 | 2 | 22 | 2 | 1 | - |
Dan James | 2 | 2 | 1 | - | 2 | - |
Hannibal Mejbri | 2 | 1 | 6 | 1 | 1 | - |
Alejandro Garnacho | 2 | - | 7 | 2 | - | - |
Shola Shoretire | 1 | - | 2 | 1 | - | - |
Tom Heaton | - | - | 13 | - | - | - |
Andreas Pereira | - | - | 1 | - | - | - |
Amad Diallo | - | - | 1 | - | - | - |
Brandon Williams | - | - | 1 | - | - | - |
Dean Henderson | - | - | 30 | - | - | - |
Alvaro Fernandez | - | - | 4 | - | - | - |
Charlie Savage | - | - | 1 | - | - | - | 532 | 418 | 341 | 114 | 114 | 56 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .