| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Lorenzo Pellegrini | 34 | 30 | 4 | 4 | 15 | 7 |
Henrikh Mkhitaryan | 34 | 30 | 4 | 4 | 5 | 13 |
Rick Karsdorp | 34 | 28 | 7 | 6 | 9 | 1 |
Bryan Cristante | 34 | 22 | 13 | 12 | 5 | 1 |
Gianluca Mancini | 33 | 33 | 1 | - | 3 | 4 |
Gonzalo Villar | 33 | 21 | 15 | 12 | 13 | - |
Borja Mayoral | 31 | 18 | 17 | 13 | 13 | 10 |
Roger Ibanez | 30 | 28 | 3 | 2 | 5 | - |
Bruno Peres | 30 | 14 | 21 | 16 | 6 | 1 |
Jordan Veretout | 29 | 25 | 4 | 4 | 14 | 10 |
Leonardo Spinazzola | 27 | 25 | 2 | 2 | 7 | 2 |
Pedro Rodriguez | 27 | 20 | 8 | 7 | 14 | 5 |
Edin Dzeko | 27 | 20 | 11 | 7 | 11 | 7 |
Pau Lopez | 21 | 20 | 13 | 1 | - | - |
Marash Kumbulla | 21 | 14 | 15 | 7 | 6 | 1 |
Carles Perez | 21 | 6 | 26 | 15 | 2 | 2 |
Amadou Diawara | 18 | 7 | 22 | 11 | 5 | 1 |
Chris Smalling | 16 | 13 | 3 | 3 | 2 | - |
Antonio Mirante | 13 | 13 | 18 | - | 1 | - |
Davide Santon | 10 | 7 | 18 | 3 | 5 | - |
Stephan El Shaaraway | 10 | 6 | 6 | 4 | 3 | 1 |
Federico Fazio | 6 | 5 | 18 | 1 | 2 | 1 |
Daniel Fuzato | 5 | 5 | 17 | - | - | - |
Ebrima Darboe | 5 | 4 | 8 | 1 | 3 | - |
Bryan Reynolds | 5 | 3 | 10 | 2 | 3 | - |
Javier Pastore | 5 | - | 19 | 5 | - | - |
Juan | 5 | - | 26 | 5 | - | - |
Riccardo Calafiori | 3 | 1 | 17 | 2 | 1 | - |
Justin Kluivert | 2 | - | 3 | 2 | - | - |
Nicola Zalewski | 1 | - | 5 | 1 | - | - |
Edoardo Bove | 1 | - | 1 | 1 | - | - |
Ruben Providence | - | - | 9 | - | - | - |
Simone Farelli | - | - | 19 | - | - | - |
Suf Podgoreanu | - | - | 9 | - | - | - |
Lamine Tall | - | - | 1 | - | - | - |
Robin Olsen | - | - | 1 | - | - | - |
Tommaso Milanese | - | - | 2 | - | - | - |
Amir Feratovic | - | - | 4 | - | - | - |
Riccardo Ciervo | - | - | 4 | - | - | - |
Mirko Antonucci | - | - | 3 | - | - | - |
Pietro Boer | - | - | 7 | - | - | - | 571 | 418 | 414 | 153 | 153 | 67 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .