| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Alisson | 37 | 37 | - | - | - | - |
Edin Dzeko | 36 | 33 | 4 | 3 | 4 | 16 |
Aleksandar Kolarov | 35 | 34 | 3 | 1 | 2 | 2 |
Stephan El Shaaraway | 34 | 26 | 11 | 8 | 17 | 7 |
Federico Fazio | 33 | 31 | 5 | 2 | - | 2 |
Alessandro Florenzi | 32 | 26 | 11 | 6 | 6 | 1 |
Kevin Strootman | 32 | 26 | 9 | 6 | 8 | 1 |
Radja Nainggolan | 31 | 31 | 3 | - | 6 | 4 |
Kostas Manolas | 30 | 28 | 7 | 2 | 6 | 2 |
Lorenzo Pellegrini | 26 | 20 | 14 | 6 | 13 | 3 |
Diego Perotti | 25 | 17 | 12 | 8 | 7 | 5 |
Cengiz Under | 25 | 14 | 22 | 11 | 15 | 7 |
Gerson | 25 | 9 | 29 | 16 | 6 | 2 |
Juan | 23 | 19 | 17 | 4 | - | - |
Daniele De Rossi | 22 | 21 | 12 | 1 | 6 | 1 |
Patrik Schick | 22 | 10 | 18 | 12 | 5 | 2 |
Bruno Peres | 18 | 13 | 20 | 5 | 4 | - |
Maxime Gonalons | 16 | 12 | 19 | 4 | 1 | - |
Gregoire Defrel | 14 | 4 | 17 | 10 | 5 | 1 |
Hector Moreno | 5 | 2 | 20 | 3 | - | - |
Luca Pellegrini | 2 | 2 | 8 | - | 1 | - |
Jonathan Silva | 2 | 1 | 13 | 1 | - | - |
Mirko Antonucci | 2 | - | 10 | 2 | - | - |
Lukasz Skorupski | 1 | 1 | 37 | - | - | - |
Rick Karsdorp | 1 | 1 | 3 | - | 1 | - |
Marco Tumminello | 1 | - | 2 | 1 | - | - |
Emerson | 1 | - | 12 | 1 | - | - |
Elio Capradossi | 1 | - | 14 | 1 | 1 | - |
Lorenzo Valeau | - | - | 1 | - | - | - |
Andrea Marcucci | - | - | 1 | - | - | - |
Leandro Castan | - | - | 15 | - | - | - |
Alessio Riccardi | - | - | 1 | - | - | - |
Devid Eugene Bouah | - | - | 1 | - | - | - |
Bogdan Lobont | - | - | 38 | - | - | - |
Abdullahi Nura | - | - | 2 | - | - | - |
Andrea Romagnoli | - | - | 1 | - | - | - | 532 | 418 | 412 | 114 | 114 | 56 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .