| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Jose Callejon | 38 | 38 | - | - | 16 | 8 |
Dries Mertens | 38 | 35 | 3 | 3 | 14 | 18 |
Marek Hamsik | 38 | 32 | 6 | 6 | 25 | 7 |
Allan | 38 | 32 | 6 | 6 | 13 | 4 |
Pepe Reina | 37 | 37 | 1 | - | - | - |
Lorenzo Insigne | 37 | 36 | 1 | 1 | 12 | 8 |
Piotr Zielinski | 36 | 14 | 24 | 22 | 8 | 5 |
Elseid Hysaj | 35 | 35 | 2 | - | 1 | - |
Kalidou Koulibaly | 35 | 35 | 1 | - | - | 5 |
Jorginho | 33 | 33 | 4 | - | 15 | 2 |
Raul Albiol | 32 | 31 | 6 | 1 | 1 | 3 |
Marko Rog | 28 | - | 38 | 28 | - | 1 |
Mario Rui | 25 | 24 | 12 | 1 | 3 | 1 |
Amadou Diawara | 18 | 5 | 32 | 13 | - | 1 |
Arkadiusz Milik | 15 | 3 | 15 | 12 | 3 | 5 |
Christian Maggio | 13 | 6 | 32 | 7 | - | - |
Faouzi Ghoulam | 11 | 11 | 2 | - | 1 | 2 |
Adam Ounas | 7 | - | 35 | 7 | - | - |
Vlad Chiriches | 6 | 6 | 23 | - | 1 | - |
Lorenzo Tonelli | 4 | 3 | 18 | 1 | - | 1 |
Emanuele Giaccherini | 4 | - | 21 | 4 | - | - |
Nikola Maksimovic | 2 | 1 | 18 | 1 | - | - |
Luigi Sepe | 1 | 1 | 37 | - | - | - |
Leandrinho | - | - | 10 | - | - | - |
Zinedine Machach | - | - | 15 | - | - | - |
Rafael Cabral | - | - | 38 | - | - | - |
Hrvoje Milic | - | - | 13 | - | - | - |
Michael Scarf | - | - | 3 | - | - | - | 531 | 418 | 416 | 113 | 113 | 71 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .