| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Marcelo Sarvas | 33 | 33 | - | - | 6 | 4 |
Sean Franklin | 33 | 29 | 4 | 4 | 2 | 1 |
Juninho | 31 | 31 | - | - | 7 | 1 |
AJ DeLaGarza | 28 | 28 | 1 | - | 5 | - |
Omar Gonzalez | 27 | 27 | - | - | 2 | 1 |
Gyasi Zardes | 27 | 23 | 4 | 4 | 7 | 4 |
Hector Jimenez | 26 | 14 | 19 | 12 | 13 | 3 |
Todd Dunivant | 25 | 25 | - | - | 2 | - |
Robbie Keane | 23 | 22 | 1 | 1 | 4 | 16 |
Landon Donovan | 22 | 21 | 1 | 1 | 1 | 10 |
Jose Villarreal | 22 | 12 | 16 | 10 | 10 | 2 |
Carlo Cudicini | 21 | 21 | - | - | - | - |
Michael Stephens | 21 | 8 | 23 | 13 | 6 | 1 |
Jack McBean | 15 | 7 | 16 | 8 | 6 | 1 |
Leonardo | 14 | 12 | 11 | 2 | 2 | - |
Greg Cochrane | 12 | 9 | 10 | 3 | - | - |
Robbie Rogers | 11 | 7 | 4 | 4 | 6 | - |
Colin Clark | 11 | 4 | 9 | 7 | 4 | - |
Mike Magee | 10 | 10 | - | - | 1 | 6 |
Jaime Penedo | 9 | 9 | 1 | - | - | - |
Pablo Mastroeni | 9 | 3 | 15 | 6 | 3 | - |
Rafael Garcia | 9 | 1 | 23 | 8 | 1 | - |
Tommy Meyer | 7 | 5 | 20 | 2 | 1 | - |
Kofi Opare | 6 | 6 | 6 | - | 1 | 1 |
Laurent Courtois | 6 | - | 9 | 6 | - | - |
Brian Rowe | 4 | 4 | 24 | - | 1 | - |
Charlie Rugg | 4 | 2 | 8 | 2 | 2 | 1 |
Kyle Nakazawa | 1 | 1 | - | - | - | - |
Oscar Sorto | - | - | 1 | - | - | - |
Bryan Gaul | - | - | 2 | - | - | - |
Brian Perk | - | - | 9 | - | - | - | 467 | 374 | 237 | 93 | 93 | 52 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .