| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Alisson | 10 | 10 | - | - | - | - |
Radja Nainggolan | 10 | 7 | 3 | 3 | 2 | 1 |
Bruno Peres | 9 | 9 | - | - | 3 | - |
Juan | 8 | 7 | 3 | 1 | - | - |
Federico Fazio | 8 | 7 | 2 | 1 | - | 2 |
Leandro Paredes | 8 | 6 | 3 | 2 | - | - |
Stephan El Shaaraway | 8 | 6 | 3 | 2 | 5 | 2 |
Edin Dzeko | 8 | 5 | 5 | 3 | 1 | 8 |
Kevin Strootman | 7 | 7 | 2 | - | 3 | 2 |
Kostas Manolas | 7 | 7 | - | - | 1 | - |
Diego Perotti | 7 | 4 | 4 | 3 | 1 | 1 |
Juan Iturbe | 6 | 5 | 1 | 1 | 3 | - |
Daniele De Rossi | 6 | 5 | 1 | 1 | 3 | 1 |
Francesco Totti | 6 | 4 | 4 | 2 | - | - |
Mohamed Salah | 6 | 4 | 5 | 2 | 2 | 2 |
Gerson | 6 | 3 | 4 | 3 | 1 | - |
Emerson | 5 | 4 | 2 | 1 | 1 | 1 |
Antonio Rudiger | 5 | 4 | 1 | 1 | 1 | - |
Alessandro Florenzi | 3 | 1 | 2 | 2 | 1 | 1 |
Thomas Vermaelen | 2 | 2 | 2 | - | - | - |
Mario Rui | 2 | 2 | 2 | - | 1 | - |
Moustapha Seck | 1 | 1 | 3 | - | - | - |
Riccardo Marchizza | 1 | - | 3 | 1 | - | - |
Davide Frattesi | - | - | 1 | - | - | - |
Lorenzo Grossi | - | - | 1 | - | - | - |
Eros De Santis | - | - | 2 | - | - | - |
Filippo Franchi | - | - | 1 | - | - | - |
Wojciech Szczesny | - | - | 10 | - | - | - | 139 | 110 | 70 | 29 | 29 | 21 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .